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Platelet count response to Helicobacter pylori eradication for idiopathic thrombocytopenic purpura in northeastern Brazil
BACKGROUND: Several studies have demonstrated that platelet counts in Helicobacter pylori-positive patients with chronic idiopathic thrombocytopenic purpura improved significantly after successful eradication of the infection. However, depending of the geographical region of the study the results ha...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Sociedade Brasileira de Hematologia e Hemoterapia
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6003102/ https://www.ncbi.nlm.nih.gov/pubmed/29519366 http://dx.doi.org/10.1016/j.bjhh.2017.09.005 |
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author | Barbosa, Alzira Maria de Castro Ribeiro, Rosangela Albuquerque Silva, Cícero Ígor Simões Moura Cruz, Francisco Will Saraiva Azevedo, Orleancio Gomes Ripardo de Pitombeira, Maria Helena da Silva Braga, Lucia Libanez Campelo |
author_facet | Barbosa, Alzira Maria de Castro Ribeiro, Rosangela Albuquerque Silva, Cícero Ígor Simões Moura Cruz, Francisco Will Saraiva Azevedo, Orleancio Gomes Ripardo de Pitombeira, Maria Helena da Silva Braga, Lucia Libanez Campelo |
author_sort | Barbosa, Alzira Maria de Castro |
collection | PubMed |
description | BACKGROUND: Several studies have demonstrated that platelet counts in Helicobacter pylori-positive patients with chronic idiopathic thrombocytopenic purpura improved significantly after successful eradication of the infection. However, depending of the geographical region of the study the results have been highly divergent. OBJECTIVE: The purpose of this study was to evaluate the effect of H. pylori eradication therapy on platelet count in a cohort of chronic idiopathic thrombocytopenic purpura patients from northeastern Brazil. METHOD: H. pylori status was determined in 28 chronic idiopathic thrombocytopenic purpura patients using the rapid urease test and histology. H. pylori-positive patients received standard triple therapy for one week. The effect of the eradication therapy was evaluated using the 13C-urea breath test two to three months after treatment. RESULTS: The prevalence of H. pylori infection was similar to that found in the general population. Twenty-two patients (78.5%) were H. pylori-positive. Fifteen were treated, 13 (86%) of whom successfully. At six months, 4/13 (30%) displayed increased platelet counts, which remained throughout follow-up (12 months). Platelet response was not associated to mean baseline platelet count, duration of chronic idiopathic thrombocytopenic purpura, gender, age, previous use of medication, or splenectomy. CONCLUSIONS: H. pylori eradication therapy showed relatively low platelet recovery rates, comparable with previous studies from southeastern Brazil. The effect of H. pylori eradication on platelet counts remained after one year of follow-up suggesting that treating H. pylori infection might be worthwhile in a subset of chronic idiopathic thrombocytopenic purpura patients. |
format | Online Article Text |
id | pubmed-6003102 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Sociedade Brasileira de Hematologia e Hemoterapia |
record_format | MEDLINE/PubMed |
spelling | pubmed-60031022018-06-18 Platelet count response to Helicobacter pylori eradication for idiopathic thrombocytopenic purpura in northeastern Brazil Barbosa, Alzira Maria de Castro Ribeiro, Rosangela Albuquerque Silva, Cícero Ígor Simões Moura Cruz, Francisco Will Saraiva Azevedo, Orleancio Gomes Ripardo de Pitombeira, Maria Helena da Silva Braga, Lucia Libanez Campelo Hematol Transfus Cell Ther Original Article BACKGROUND: Several studies have demonstrated that platelet counts in Helicobacter pylori-positive patients with chronic idiopathic thrombocytopenic purpura improved significantly after successful eradication of the infection. However, depending of the geographical region of the study the results have been highly divergent. OBJECTIVE: The purpose of this study was to evaluate the effect of H. pylori eradication therapy on platelet count in a cohort of chronic idiopathic thrombocytopenic purpura patients from northeastern Brazil. METHOD: H. pylori status was determined in 28 chronic idiopathic thrombocytopenic purpura patients using the rapid urease test and histology. H. pylori-positive patients received standard triple therapy for one week. The effect of the eradication therapy was evaluated using the 13C-urea breath test two to three months after treatment. RESULTS: The prevalence of H. pylori infection was similar to that found in the general population. Twenty-two patients (78.5%) were H. pylori-positive. Fifteen were treated, 13 (86%) of whom successfully. At six months, 4/13 (30%) displayed increased platelet counts, which remained throughout follow-up (12 months). Platelet response was not associated to mean baseline platelet count, duration of chronic idiopathic thrombocytopenic purpura, gender, age, previous use of medication, or splenectomy. CONCLUSIONS: H. pylori eradication therapy showed relatively low platelet recovery rates, comparable with previous studies from southeastern Brazil. The effect of H. pylori eradication on platelet counts remained after one year of follow-up suggesting that treating H. pylori infection might be worthwhile in a subset of chronic idiopathic thrombocytopenic purpura patients. Sociedade Brasileira de Hematologia e Hemoterapia 2018 2017-11-24 /pmc/articles/PMC6003102/ /pubmed/29519366 http://dx.doi.org/10.1016/j.bjhh.2017.09.005 Text en © 2017 Published by Elsevier Editora Ltda. on behalf of Associação Brasileira de Hematologia, Hemoterapia e Terapia Celular. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Original Article Barbosa, Alzira Maria de Castro Ribeiro, Rosangela Albuquerque Silva, Cícero Ígor Simões Moura Cruz, Francisco Will Saraiva Azevedo, Orleancio Gomes Ripardo de Pitombeira, Maria Helena da Silva Braga, Lucia Libanez Campelo Platelet count response to Helicobacter pylori eradication for idiopathic thrombocytopenic purpura in northeastern Brazil |
title | Platelet count response to Helicobacter pylori eradication for idiopathic thrombocytopenic purpura in northeastern Brazil |
title_full | Platelet count response to Helicobacter pylori eradication for idiopathic thrombocytopenic purpura in northeastern Brazil |
title_fullStr | Platelet count response to Helicobacter pylori eradication for idiopathic thrombocytopenic purpura in northeastern Brazil |
title_full_unstemmed | Platelet count response to Helicobacter pylori eradication for idiopathic thrombocytopenic purpura in northeastern Brazil |
title_short | Platelet count response to Helicobacter pylori eradication for idiopathic thrombocytopenic purpura in northeastern Brazil |
title_sort | platelet count response to helicobacter pylori eradication for idiopathic thrombocytopenic purpura in northeastern brazil |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6003102/ https://www.ncbi.nlm.nih.gov/pubmed/29519366 http://dx.doi.org/10.1016/j.bjhh.2017.09.005 |
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