Doxorubicin-induced cardiotoxicity is suppressed by estrous-staged treatment and exogenous 17β-estradiol in female tumor-bearing spontaneously hypertensive rats

BACKGROUND: Doxorubicin (DOX), an anthracycline therapeutic, is widely used to treat a variety of cancer types and known to induce cardiomyopathy in a time and dose-dependent manner. Postmenopausal and hypertensive females are two high-risk groups for developing adverse effects following DOX treatme...

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Detalles Bibliográficos
Autores principales: Pokrzywinski, Kaytee L., Biel, Thomas G., Rosen, Elliot T., Bonanno, Julia L., Aryal, Baikuntha, Mascia, Francesca, Moshkelani, Delaram, Mog, Steven, Rao, V. Ashutosh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6003183/
https://www.ncbi.nlm.nih.gov/pubmed/29907135
http://dx.doi.org/10.1186/s13293-018-0183-9

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