JNK-mediated microglial DICER degradation potentiates inflammatory responses to induce dopaminergic neuron loss

BACKGROUND: Amplified inflammation is important for the progression of Parkinson’s disease (PD). However, how this enhanced inflammation is regulated remains largely unknown. Deletion of DICER leads to progressive dopamine neuronal loss and induces gliosis. We hypothesized that the homeostasis of mi...

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Detalles Bibliográficos
Autores principales: Wang, Qing, He, Qian, Chen, Yifei, Shao, Wei, Yuan, Chao, Wang, Yizheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6003208/
https://www.ncbi.nlm.nih.gov/pubmed/29907159
http://dx.doi.org/10.1186/s12974-018-1218-1

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