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Gamma Delta T Cell Therapy for Cancer: It Is Good to be Local
Human gamma delta T cells have extraordinary properties including the capacity for tumor cell killing. The major gamma delta T cell subset in human beings is designated Vγ9Vδ2 and is activated by intermediates of isoprenoid biosynthesis or aminobisphosphonate inhibitors of farnesyldiphosphate syntha...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6003257/ https://www.ncbi.nlm.nih.gov/pubmed/29937769 http://dx.doi.org/10.3389/fimmu.2018.01305 |
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author | Pauza, C. David Liou, Mei-Ling Lahusen, Tyler Xiao, Lingzhi Lapidus, Rena G. Cairo, Cristiana Li, Haishan |
author_facet | Pauza, C. David Liou, Mei-Ling Lahusen, Tyler Xiao, Lingzhi Lapidus, Rena G. Cairo, Cristiana Li, Haishan |
author_sort | Pauza, C. David |
collection | PubMed |
description | Human gamma delta T cells have extraordinary properties including the capacity for tumor cell killing. The major gamma delta T cell subset in human beings is designated Vγ9Vδ2 and is activated by intermediates of isoprenoid biosynthesis or aminobisphosphonate inhibitors of farnesyldiphosphate synthase. Activated cells are potent for killing a broad range of tumor cells and demonstrated the capacity for tumor reduction in murine xenotransplant tumor models. Translating these findings to the clinic produced promising initial results but greater potency is needed. Here, we review the literature on gamma delta T cells in cancer therapy with emphasis on the Vγ9Vδ2 T cell subset. Our goal was to examine obstacles preventing effective Vγ9Vδ2 T cell therapy and strategies for overcoming them. We focus on the potential for local activation of Vγ9Vδ2 T cells within the tumor environment to increase potency and achieve objective responses during cancer therapy. The gamma delta T cells and especially the Vγ9Vδ2 T cell subset, have the potential to overcome many problems in cancer therapy especially for tumors with no known treatment, lacking tumor-specific antigens for targeting by antibodies and CAR-T, or unresponsive to immune checkpoint inhibitors. Translation of amazing work from many laboratories studying gamma delta T cells is needed to fulfill the promise of effective and safe cancer immunotherapy. |
format | Online Article Text |
id | pubmed-6003257 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-60032572018-06-22 Gamma Delta T Cell Therapy for Cancer: It Is Good to be Local Pauza, C. David Liou, Mei-Ling Lahusen, Tyler Xiao, Lingzhi Lapidus, Rena G. Cairo, Cristiana Li, Haishan Front Immunol Immunology Human gamma delta T cells have extraordinary properties including the capacity for tumor cell killing. The major gamma delta T cell subset in human beings is designated Vγ9Vδ2 and is activated by intermediates of isoprenoid biosynthesis or aminobisphosphonate inhibitors of farnesyldiphosphate synthase. Activated cells are potent for killing a broad range of tumor cells and demonstrated the capacity for tumor reduction in murine xenotransplant tumor models. Translating these findings to the clinic produced promising initial results but greater potency is needed. Here, we review the literature on gamma delta T cells in cancer therapy with emphasis on the Vγ9Vδ2 T cell subset. Our goal was to examine obstacles preventing effective Vγ9Vδ2 T cell therapy and strategies for overcoming them. We focus on the potential for local activation of Vγ9Vδ2 T cells within the tumor environment to increase potency and achieve objective responses during cancer therapy. The gamma delta T cells and especially the Vγ9Vδ2 T cell subset, have the potential to overcome many problems in cancer therapy especially for tumors with no known treatment, lacking tumor-specific antigens for targeting by antibodies and CAR-T, or unresponsive to immune checkpoint inhibitors. Translation of amazing work from many laboratories studying gamma delta T cells is needed to fulfill the promise of effective and safe cancer immunotherapy. Frontiers Media S.A. 2018-06-08 /pmc/articles/PMC6003257/ /pubmed/29937769 http://dx.doi.org/10.3389/fimmu.2018.01305 Text en Copyright © 2018 Pauza, Liou, Lahusen, Xiao, Lapidus, Cairo and Li. https://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Immunology Pauza, C. David Liou, Mei-Ling Lahusen, Tyler Xiao, Lingzhi Lapidus, Rena G. Cairo, Cristiana Li, Haishan Gamma Delta T Cell Therapy for Cancer: It Is Good to be Local |
title | Gamma Delta T Cell Therapy for Cancer: It Is Good to be Local |
title_full | Gamma Delta T Cell Therapy for Cancer: It Is Good to be Local |
title_fullStr | Gamma Delta T Cell Therapy for Cancer: It Is Good to be Local |
title_full_unstemmed | Gamma Delta T Cell Therapy for Cancer: It Is Good to be Local |
title_short | Gamma Delta T Cell Therapy for Cancer: It Is Good to be Local |
title_sort | gamma delta t cell therapy for cancer: it is good to be local |
topic | Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6003257/ https://www.ncbi.nlm.nih.gov/pubmed/29937769 http://dx.doi.org/10.3389/fimmu.2018.01305 |
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