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CK1δ/ε protein kinase primes the PER2 circadian phosphoswitch

Multisite phosphorylation of the PERIOD 2 (PER2) protein is the key step that determines the period of the mammalian circadian clock. Previous studies concluded that an unidentified kinase is required to prime PER2 for subsequent phosphorylation by casein kinase 1 (CK1), an essential clock component...

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Detalles Bibliográficos
Autores principales:	Narasimamurthy, Rajesh, Hunt, Sabrina R., Lu, Yining, Fustin, Jean-Michel, Okamura, Hitoshi, Partch, Carrie L., Forger, Daniel B., Kim, Jae Kyoung, Virshup, David M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	National Academy of Sciences 2018
Materias:	Biological Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6003379/ https://www.ncbi.nlm.nih.gov/pubmed/29784789 http://dx.doi.org/10.1073/pnas.1721076115

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