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Impact of lower uterine segment involvement in type II endometrial cancer and the unique mutational profile of serous tumors
OBJECTIVE: Evaluation of the impact of lower uterine segment involvement (LUSI) in type II endometrial cancer, and mutational profile of uterine papillary serous carcinomas (UPSC). METHODS: Retrospective cohort study comparing patients with type II endometrial cancer with LUSI to patients without LU...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6003406/ https://www.ncbi.nlm.nih.gov/pubmed/29915797 http://dx.doi.org/10.1016/j.gore.2018.03.004 |
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author | Kogan, Liron Octeau, David Amajoud, Zainab Abitbol, Jeremie Laskov, Ido Ferenczy, Alex Pelmus, Manuela Eisenberg, Neta Kessous, Roy Lau, Susie Yasmeen, Amber Gotlieb, Walter H. Salvador, Shannon |
author_facet | Kogan, Liron Octeau, David Amajoud, Zainab Abitbol, Jeremie Laskov, Ido Ferenczy, Alex Pelmus, Manuela Eisenberg, Neta Kessous, Roy Lau, Susie Yasmeen, Amber Gotlieb, Walter H. Salvador, Shannon |
author_sort | Kogan, Liron |
collection | PubMed |
description | OBJECTIVE: Evaluation of the impact of lower uterine segment involvement (LUSI) in type II endometrial cancer, and mutational profile of uterine papillary serous carcinomas (UPSC). METHODS: Retrospective cohort study comparing patients with type II endometrial cancer with LUSI to patients without LUSI. Genes commonly implicated in carcinogenesis were analyzed in a subgroup of 42 patients with UPSC using next generation sequencing. RESULTS: 83 patients with type II endometrial cancer were included in the study, of these, LUSI was diagnosed in 31.3%. During a median follow-up of 45.5 months, patients with LUSI developed more local and distant recurrences (local: 19.2% vs. 3.5%, P = .03; distant: 50% vs. 17.5%, P = .004) and progression events (73.1% vs. 26.3%, P < .001), with shorter mean progression-free survival (16 months compared to 26.5 months, P < .01). In a multivariate analysis, LUSI was the only significant pathological factor, associated with a 2.9-fold increase in the risk of progression (P = .007), and a 2.6-fold increase in the risk of death (P = .02). In the subgroup of patients with UPSC, mutations were identified in 54 genes, including TP53 (80%), PPP2R1A (40%), and PTEN (22.5%). Frequent mutations in the PTEN-PI3K-AKT signaling pathway were found in patients with tumor in the upper uterine segment only (P = .04), with PTEN being mutated in 29% of the samples (P = .07). CONCLUSION: Type II endometrial cancers presenting in the LUS have a significantly worse prognosis and this might be associated with a unique mutational profile. |
format | Online Article Text |
id | pubmed-6003406 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-60034062018-06-18 Impact of lower uterine segment involvement in type II endometrial cancer and the unique mutational profile of serous tumors Kogan, Liron Octeau, David Amajoud, Zainab Abitbol, Jeremie Laskov, Ido Ferenczy, Alex Pelmus, Manuela Eisenberg, Neta Kessous, Roy Lau, Susie Yasmeen, Amber Gotlieb, Walter H. Salvador, Shannon Gynecol Oncol Rep Case Series OBJECTIVE: Evaluation of the impact of lower uterine segment involvement (LUSI) in type II endometrial cancer, and mutational profile of uterine papillary serous carcinomas (UPSC). METHODS: Retrospective cohort study comparing patients with type II endometrial cancer with LUSI to patients without LUSI. Genes commonly implicated in carcinogenesis were analyzed in a subgroup of 42 patients with UPSC using next generation sequencing. RESULTS: 83 patients with type II endometrial cancer were included in the study, of these, LUSI was diagnosed in 31.3%. During a median follow-up of 45.5 months, patients with LUSI developed more local and distant recurrences (local: 19.2% vs. 3.5%, P = .03; distant: 50% vs. 17.5%, P = .004) and progression events (73.1% vs. 26.3%, P < .001), with shorter mean progression-free survival (16 months compared to 26.5 months, P < .01). In a multivariate analysis, LUSI was the only significant pathological factor, associated with a 2.9-fold increase in the risk of progression (P = .007), and a 2.6-fold increase in the risk of death (P = .02). In the subgroup of patients with UPSC, mutations were identified in 54 genes, including TP53 (80%), PPP2R1A (40%), and PTEN (22.5%). Frequent mutations in the PTEN-PI3K-AKT signaling pathway were found in patients with tumor in the upper uterine segment only (P = .04), with PTEN being mutated in 29% of the samples (P = .07). CONCLUSION: Type II endometrial cancers presenting in the LUS have a significantly worse prognosis and this might be associated with a unique mutational profile. Elsevier 2018-03-19 /pmc/articles/PMC6003406/ /pubmed/29915797 http://dx.doi.org/10.1016/j.gore.2018.03.004 Text en © 2018 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Case Series Kogan, Liron Octeau, David Amajoud, Zainab Abitbol, Jeremie Laskov, Ido Ferenczy, Alex Pelmus, Manuela Eisenberg, Neta Kessous, Roy Lau, Susie Yasmeen, Amber Gotlieb, Walter H. Salvador, Shannon Impact of lower uterine segment involvement in type II endometrial cancer and the unique mutational profile of serous tumors |
title | Impact of lower uterine segment involvement in type II endometrial cancer and the unique mutational profile of serous tumors |
title_full | Impact of lower uterine segment involvement in type II endometrial cancer and the unique mutational profile of serous tumors |
title_fullStr | Impact of lower uterine segment involvement in type II endometrial cancer and the unique mutational profile of serous tumors |
title_full_unstemmed | Impact of lower uterine segment involvement in type II endometrial cancer and the unique mutational profile of serous tumors |
title_short | Impact of lower uterine segment involvement in type II endometrial cancer and the unique mutational profile of serous tumors |
title_sort | impact of lower uterine segment involvement in type ii endometrial cancer and the unique mutational profile of serous tumors |
topic | Case Series |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6003406/ https://www.ncbi.nlm.nih.gov/pubmed/29915797 http://dx.doi.org/10.1016/j.gore.2018.03.004 |
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