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Lymph node density in papillary thyroid carcinoma is a prognostic factor after adjusting for pathological stage
We investigated the possible association between the lymph node density and survival outcomes in differentiated papillary thyroid carcinoma, and examined whether the lymph node density was a predictor in a multivariate analysis adjusted for the pathological stage in the eighth edition of the Union f...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6003559/ https://www.ncbi.nlm.nih.gov/pubmed/29928477 http://dx.doi.org/10.18632/oncotarget.25453 |
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author | Suzuki, Hidenori Koide, Yusuke Hanai, Nobuhiro Nishikawa, Daisuke Beppu, Shintaro Mikami, Shinji Hasegawa, Yasuhisa |
author_facet | Suzuki, Hidenori Koide, Yusuke Hanai, Nobuhiro Nishikawa, Daisuke Beppu, Shintaro Mikami, Shinji Hasegawa, Yasuhisa |
author_sort | Suzuki, Hidenori |
collection | PubMed |
description | We investigated the possible association between the lymph node density and survival outcomes in differentiated papillary thyroid carcinoma, and examined whether the lymph node density was a predictor in a multivariate analysis adjusted for the pathological stage in the eighth edition of the Union for International Cancer Control Tumor-Node Metastasis Classification of Malignant Tumors. A total of 543 patients with papillary thyroid carcinoma were enrolled. We performed restaging according to the eighth edition. The lymph node density was the ratio between number of positive lymph nodes and total number of excised lymph nodes. A log-rank test and Cox's proportional hazards model were used for univariate and multivariate analysis with adjustment for the pathological stage in the eighth edition, respectively. In both the univariate and multivariate analyses of 150 patients with pN1bM0, the presence of a lymph node density of ≥ 0.3 with pN1b was significantly associated with shorter disease-specific survival. In both the univariate and multivariate analyses of all 543 patients, a lymph node density of ≥ 0.3 with pN1b were also significantly associated with shorter overall and disease-specific survival. In conclusion, these results suggest that the lymph node density can be used as a predictor for the survival outcomes after adjustment for the pathological stage in the eighth edition. |
format | Online Article Text |
id | pubmed-6003559 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Impact Journals LLC |
record_format | MEDLINE/PubMed |
spelling | pubmed-60035592018-06-20 Lymph node density in papillary thyroid carcinoma is a prognostic factor after adjusting for pathological stage Suzuki, Hidenori Koide, Yusuke Hanai, Nobuhiro Nishikawa, Daisuke Beppu, Shintaro Mikami, Shinji Hasegawa, Yasuhisa Oncotarget Research Paper We investigated the possible association between the lymph node density and survival outcomes in differentiated papillary thyroid carcinoma, and examined whether the lymph node density was a predictor in a multivariate analysis adjusted for the pathological stage in the eighth edition of the Union for International Cancer Control Tumor-Node Metastasis Classification of Malignant Tumors. A total of 543 patients with papillary thyroid carcinoma were enrolled. We performed restaging according to the eighth edition. The lymph node density was the ratio between number of positive lymph nodes and total number of excised lymph nodes. A log-rank test and Cox's proportional hazards model were used for univariate and multivariate analysis with adjustment for the pathological stage in the eighth edition, respectively. In both the univariate and multivariate analyses of 150 patients with pN1bM0, the presence of a lymph node density of ≥ 0.3 with pN1b was significantly associated with shorter disease-specific survival. In both the univariate and multivariate analyses of all 543 patients, a lymph node density of ≥ 0.3 with pN1b were also significantly associated with shorter overall and disease-specific survival. In conclusion, these results suggest that the lymph node density can be used as a predictor for the survival outcomes after adjustment for the pathological stage in the eighth edition. Impact Journals LLC 2018-06-01 /pmc/articles/PMC6003559/ /pubmed/29928477 http://dx.doi.org/10.18632/oncotarget.25453 Text en Copyright: © 2018 Suzuki et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License 3.0 (http://creativecommons.org/licenses/by/3.0/) (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Paper Suzuki, Hidenori Koide, Yusuke Hanai, Nobuhiro Nishikawa, Daisuke Beppu, Shintaro Mikami, Shinji Hasegawa, Yasuhisa Lymph node density in papillary thyroid carcinoma is a prognostic factor after adjusting for pathological stage |
title | Lymph node density in papillary thyroid carcinoma is a prognostic factor after adjusting for pathological stage |
title_full | Lymph node density in papillary thyroid carcinoma is a prognostic factor after adjusting for pathological stage |
title_fullStr | Lymph node density in papillary thyroid carcinoma is a prognostic factor after adjusting for pathological stage |
title_full_unstemmed | Lymph node density in papillary thyroid carcinoma is a prognostic factor after adjusting for pathological stage |
title_short | Lymph node density in papillary thyroid carcinoma is a prognostic factor after adjusting for pathological stage |
title_sort | lymph node density in papillary thyroid carcinoma is a prognostic factor after adjusting for pathological stage |
topic | Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6003559/ https://www.ncbi.nlm.nih.gov/pubmed/29928477 http://dx.doi.org/10.18632/oncotarget.25453 |
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