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Lymph node density in papillary thyroid carcinoma is a prognostic factor after adjusting for pathological stage

We investigated the possible association between the lymph node density and survival outcomes in differentiated papillary thyroid carcinoma, and examined whether the lymph node density was a predictor in a multivariate analysis adjusted for the pathological stage in the eighth edition of the Union f...

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Autores principales: Suzuki, Hidenori, Koide, Yusuke, Hanai, Nobuhiro, Nishikawa, Daisuke, Beppu, Shintaro, Mikami, Shinji, Hasegawa, Yasuhisa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6003559/
https://www.ncbi.nlm.nih.gov/pubmed/29928477
http://dx.doi.org/10.18632/oncotarget.25453
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author Suzuki, Hidenori
Koide, Yusuke
Hanai, Nobuhiro
Nishikawa, Daisuke
Beppu, Shintaro
Mikami, Shinji
Hasegawa, Yasuhisa
author_facet Suzuki, Hidenori
Koide, Yusuke
Hanai, Nobuhiro
Nishikawa, Daisuke
Beppu, Shintaro
Mikami, Shinji
Hasegawa, Yasuhisa
author_sort Suzuki, Hidenori
collection PubMed
description We investigated the possible association between the lymph node density and survival outcomes in differentiated papillary thyroid carcinoma, and examined whether the lymph node density was a predictor in a multivariate analysis adjusted for the pathological stage in the eighth edition of the Union for International Cancer Control Tumor-Node Metastasis Classification of Malignant Tumors. A total of 543 patients with papillary thyroid carcinoma were enrolled. We performed restaging according to the eighth edition. The lymph node density was the ratio between number of positive lymph nodes and total number of excised lymph nodes. A log-rank test and Cox's proportional hazards model were used for univariate and multivariate analysis with adjustment for the pathological stage in the eighth edition, respectively. In both the univariate and multivariate analyses of 150 patients with pN1bM0, the presence of a lymph node density of ≥ 0.3 with pN1b was significantly associated with shorter disease-specific survival. In both the univariate and multivariate analyses of all 543 patients, a lymph node density of ≥ 0.3 with pN1b were also significantly associated with shorter overall and disease-specific survival. In conclusion, these results suggest that the lymph node density can be used as a predictor for the survival outcomes after adjustment for the pathological stage in the eighth edition.
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spelling pubmed-60035592018-06-20 Lymph node density in papillary thyroid carcinoma is a prognostic factor after adjusting for pathological stage Suzuki, Hidenori Koide, Yusuke Hanai, Nobuhiro Nishikawa, Daisuke Beppu, Shintaro Mikami, Shinji Hasegawa, Yasuhisa Oncotarget Research Paper We investigated the possible association between the lymph node density and survival outcomes in differentiated papillary thyroid carcinoma, and examined whether the lymph node density was a predictor in a multivariate analysis adjusted for the pathological stage in the eighth edition of the Union for International Cancer Control Tumor-Node Metastasis Classification of Malignant Tumors. A total of 543 patients with papillary thyroid carcinoma were enrolled. We performed restaging according to the eighth edition. The lymph node density was the ratio between number of positive lymph nodes and total number of excised lymph nodes. A log-rank test and Cox's proportional hazards model were used for univariate and multivariate analysis with adjustment for the pathological stage in the eighth edition, respectively. In both the univariate and multivariate analyses of 150 patients with pN1bM0, the presence of a lymph node density of ≥ 0.3 with pN1b was significantly associated with shorter disease-specific survival. In both the univariate and multivariate analyses of all 543 patients, a lymph node density of ≥ 0.3 with pN1b were also significantly associated with shorter overall and disease-specific survival. In conclusion, these results suggest that the lymph node density can be used as a predictor for the survival outcomes after adjustment for the pathological stage in the eighth edition. Impact Journals LLC 2018-06-01 /pmc/articles/PMC6003559/ /pubmed/29928477 http://dx.doi.org/10.18632/oncotarget.25453 Text en Copyright: © 2018 Suzuki et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License 3.0 (http://creativecommons.org/licenses/by/3.0/) (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Paper
Suzuki, Hidenori
Koide, Yusuke
Hanai, Nobuhiro
Nishikawa, Daisuke
Beppu, Shintaro
Mikami, Shinji
Hasegawa, Yasuhisa
Lymph node density in papillary thyroid carcinoma is a prognostic factor after adjusting for pathological stage
title Lymph node density in papillary thyroid carcinoma is a prognostic factor after adjusting for pathological stage
title_full Lymph node density in papillary thyroid carcinoma is a prognostic factor after adjusting for pathological stage
title_fullStr Lymph node density in papillary thyroid carcinoma is a prognostic factor after adjusting for pathological stage
title_full_unstemmed Lymph node density in papillary thyroid carcinoma is a prognostic factor after adjusting for pathological stage
title_short Lymph node density in papillary thyroid carcinoma is a prognostic factor after adjusting for pathological stage
title_sort lymph node density in papillary thyroid carcinoma is a prognostic factor after adjusting for pathological stage
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6003559/
https://www.ncbi.nlm.nih.gov/pubmed/29928477
http://dx.doi.org/10.18632/oncotarget.25453
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