Cargando…
Viral Macrodomains: Unique Mediators of Viral Replication and Pathogenesis
Viruses from the Coronaviridae, Togaviridae, and Hepeviridae families all contain genes that encode a conserved protein domain, called a macrodomain; however, the role of this domain during infection has remained enigmatic. The recent discovery that mammalian macrodomain proteins enzymatically remo...
Autores principales: | Fehr, Anthony R., Jankevicius, Gytis, Ahel, Ivan, Perlman, Stanley |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier Ltd.
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6003825/ https://www.ncbi.nlm.nih.gov/pubmed/29268982 http://dx.doi.org/10.1016/j.tim.2017.11.011 |
Ejemplares similares
-
The Conserved Coronavirus Macrodomain Promotes Virulence and Suppresses the Innate Immune Response during Severe Acute Respiratory Syndrome Coronavirus Infection
por: Fehr, Anthony R., et al.
Publicado: (2016) -
The Viral Macrodomain Counters Host Antiviral ADP-Ribosylation
por: Alhammad, Yousef M. O., et al.
Publicado: (2020) -
Viral macrodomains: a structural and evolutionary assessment of the pharmacological potential
por: Rack, Johannes Gregor Matthias, et al.
Publicado: (2020) -
Disruption of Macrodomain Protein SCO6735 Increases Antibiotic Production in Streptomyces coelicolor
por: Lalić, Jasna, et al.
Publicado: (2016) -
The coronavirus macrodomain is required to prevent PARP-mediated inhibition of virus replication and enhancement of IFN expression
por: Grunewald, Matthew E., et al.
Publicado: (2019)