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Size matters: conserved proteins function in length-dependent nuclear export of circular RNAs
Circular RNAs (circRNAs) comprise a recently appreciated category of RNAs that are in high abundance and serve important biological functions. Although several discoveries have been made regarding the biogenesis and functions of circRNAs, their subcellular trafficking has remained largely unknown. I...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cold Spring Harbor Laboratory Press
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6004075/ https://www.ncbi.nlm.nih.gov/pubmed/29802122 http://dx.doi.org/10.1101/gad.316216.118 |
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author | Wan, Yao Hopper, Anita K. |
author_facet | Wan, Yao Hopper, Anita K. |
author_sort | Wan, Yao |
collection | PubMed |
description | Circular RNAs (circRNAs) comprise a recently appreciated category of RNAs that are in high abundance and serve important biological functions. Although several discoveries have been made regarding the biogenesis and functions of circRNAs, their subcellular trafficking has remained largely unknown. In this issue of Genes & Development, Huang and colleagues (pp. 639–644) reported the first study of the nuclear export of circRNAs. Drosophila Hel25E and its human homologs, UAP56 and URH49, are required for nuclear export of circRNAs. Nuclear export of circRNAs is surprisingly length-dependent, and the length measurement mechanism was shown to be controlled by motifs in Hel25E and its homologs consisting of four amino acids. |
format | Online Article Text |
id | pubmed-6004075 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Cold Spring Harbor Laboratory Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-60040752018-11-01 Size matters: conserved proteins function in length-dependent nuclear export of circular RNAs Wan, Yao Hopper, Anita K. Genes Dev Outlook Circular RNAs (circRNAs) comprise a recently appreciated category of RNAs that are in high abundance and serve important biological functions. Although several discoveries have been made regarding the biogenesis and functions of circRNAs, their subcellular trafficking has remained largely unknown. In this issue of Genes & Development, Huang and colleagues (pp. 639–644) reported the first study of the nuclear export of circRNAs. Drosophila Hel25E and its human homologs, UAP56 and URH49, are required for nuclear export of circRNAs. Nuclear export of circRNAs is surprisingly length-dependent, and the length measurement mechanism was shown to be controlled by motifs in Hel25E and its homologs consisting of four amino acids. Cold Spring Harbor Laboratory Press 2018-05-01 /pmc/articles/PMC6004075/ /pubmed/29802122 http://dx.doi.org/10.1101/gad.316216.118 Text en © 2018 Wan and Hopper; Published by Cold Spring Harbor Laboratory Press http://creativecommons.org/licenses/by-nc/4.0/ This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first six months after the full-issue publication date (see http://genesdev.cshlp.org/site/misc/terms.xhtml). After six months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/. |
spellingShingle | Outlook Wan, Yao Hopper, Anita K. Size matters: conserved proteins function in length-dependent nuclear export of circular RNAs |
title | Size matters: conserved proteins function in length-dependent nuclear export of circular RNAs |
title_full | Size matters: conserved proteins function in length-dependent nuclear export of circular RNAs |
title_fullStr | Size matters: conserved proteins function in length-dependent nuclear export of circular RNAs |
title_full_unstemmed | Size matters: conserved proteins function in length-dependent nuclear export of circular RNAs |
title_short | Size matters: conserved proteins function in length-dependent nuclear export of circular RNAs |
title_sort | size matters: conserved proteins function in length-dependent nuclear export of circular rnas |
topic | Outlook |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6004075/ https://www.ncbi.nlm.nih.gov/pubmed/29802122 http://dx.doi.org/10.1101/gad.316216.118 |
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