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IMP/GTP balance modulates cytoophidium assembly and IMPDH activity

BACKGROUND: Inosine monophosphate dehydrogenase (IMPDH), the rate-limiting enzyme in de novo GTP biosynthesis, plays an important role in cell metabolism and proliferation. It has been demonstrated that IMPDH can aggregate into a macrostructure, termed the cytoophidium, in mammalian cells under a va...

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Detalles Bibliográficos
Autores principales:	Keppeke, Gerson Dierley, Chang, Chia Chun, Peng, Min, Chen, Li-Yu, Lin, Wei-Cheng, Pai, Li-Mei, Andrade, Luis Eduardo Coelho, Sung, Li-Ying, Liu, Ji-Long
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2018
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6004095/ https://www.ncbi.nlm.nih.gov/pubmed/29946345 http://dx.doi.org/10.1186/s13008-018-0038-0

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