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High Grade B- Cell Non- Hodgkin’s Lymphoma Arising in a Mature Cystic Teratoma of The Ovary: A Case Report

Mature cystic teratoma (MCT) is the most common type of ovarian germ cell tumor occurring in females of reproductive age. It is typically benign, but rare malignant transformations have been reported in 1-2% of the cases. Among a wide variety of malignancies arising in MCTs, high grade lymphomas are...

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Autores principales: Afzal, Sameen, Zaman, Samina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Babol University of Medical Sciences 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6004291/
https://www.ncbi.nlm.nih.gov/pubmed/29988216
http://dx.doi.org/10.22088/BUMS.6.4.239
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author Afzal, Sameen
Zaman, Samina
author_facet Afzal, Sameen
Zaman, Samina
author_sort Afzal, Sameen
collection PubMed
description Mature cystic teratoma (MCT) is the most common type of ovarian germ cell tumor occurring in females of reproductive age. It is typically benign, but rare malignant transformations have been reported in 1-2% of the cases. Among a wide variety of malignancies arising in MCTs, high grade lymphomas are the least common. We present a case of a 45- years -old female with a unilateral adnexal mass. Gross examination revealed a unilocular cyst with a smooth and intact capsule. The cyst lumen was filled with sebaceous material and hair. Except for a 5.0 cm Rokitansky nodule, no other nodule or papillary structures were identified. Microscopic examination revealed an array of mature tissues arising from different germ cell layers, and foci of diffuse sheets of large atypical lymphoid cells. These were positive for CD-20 marker, confirming their B lymphoid series cell origin. A final diagnosis of a high grade B cell non Hodgkin’s lymphoma arising in an ovarian MCT was made. Such cases have been known to be associated with a very poor prognosis, and there are no established criteria for their pre-operative diagnosis. Risk factors for malignant transformation in an MCT including tumor size, post menopausal status and serum tumor markers are thus analyzed routinely to make a presumptive diagnosis. These coupled with extensive gross sampling of the tumor specimens, and a diligent histopathological examination may aid in an accurate diagnosis of a malignant neoplasm arising in MCTs.
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spelling pubmed-60042912018-07-09 High Grade B- Cell Non- Hodgkin’s Lymphoma Arising in a Mature Cystic Teratoma of The Ovary: A Case Report Afzal, Sameen Zaman, Samina Int J Mol Cell Med Case Report Mature cystic teratoma (MCT) is the most common type of ovarian germ cell tumor occurring in females of reproductive age. It is typically benign, but rare malignant transformations have been reported in 1-2% of the cases. Among a wide variety of malignancies arising in MCTs, high grade lymphomas are the least common. We present a case of a 45- years -old female with a unilateral adnexal mass. Gross examination revealed a unilocular cyst with a smooth and intact capsule. The cyst lumen was filled with sebaceous material and hair. Except for a 5.0 cm Rokitansky nodule, no other nodule or papillary structures were identified. Microscopic examination revealed an array of mature tissues arising from different germ cell layers, and foci of diffuse sheets of large atypical lymphoid cells. These were positive for CD-20 marker, confirming their B lymphoid series cell origin. A final diagnosis of a high grade B cell non Hodgkin’s lymphoma arising in an ovarian MCT was made. Such cases have been known to be associated with a very poor prognosis, and there are no established criteria for their pre-operative diagnosis. Risk factors for malignant transformation in an MCT including tumor size, post menopausal status and serum tumor markers are thus analyzed routinely to make a presumptive diagnosis. These coupled with extensive gross sampling of the tumor specimens, and a diligent histopathological examination may aid in an accurate diagnosis of a malignant neoplasm arising in MCTs. Babol University of Medical Sciences 2017 2018-02-10 /pmc/articles/PMC6004291/ /pubmed/29988216 http://dx.doi.org/10.22088/BUMS.6.4.239 Text en This is an Open Access article distributed under the terms of the Creative Commons Attribution License, (http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Afzal, Sameen
Zaman, Samina
High Grade B- Cell Non- Hodgkin’s Lymphoma Arising in a Mature Cystic Teratoma of The Ovary: A Case Report
title High Grade B- Cell Non- Hodgkin’s Lymphoma Arising in a Mature Cystic Teratoma of The Ovary: A Case Report
title_full High Grade B- Cell Non- Hodgkin’s Lymphoma Arising in a Mature Cystic Teratoma of The Ovary: A Case Report
title_fullStr High Grade B- Cell Non- Hodgkin’s Lymphoma Arising in a Mature Cystic Teratoma of The Ovary: A Case Report
title_full_unstemmed High Grade B- Cell Non- Hodgkin’s Lymphoma Arising in a Mature Cystic Teratoma of The Ovary: A Case Report
title_short High Grade B- Cell Non- Hodgkin’s Lymphoma Arising in a Mature Cystic Teratoma of The Ovary: A Case Report
title_sort high grade b- cell non- hodgkin’s lymphoma arising in a mature cystic teratoma of the ovary: a case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6004291/
https://www.ncbi.nlm.nih.gov/pubmed/29988216
http://dx.doi.org/10.22088/BUMS.6.4.239
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