XK-related protein 5 (XKR5) is a novel negative regulator of KIT/D816V-mediated transformation

In order to investigate the molecular mechanisms by which the oncogenic mutant KIT/D816V causes transformation of cells, we investigated proteins that selectively bind KIT/D816V, but not wild-type KIT, as potential mediators of transformation. By mass spectrometry several proteins were identified, a...

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Detalles Bibliográficos
Autores principales: Sun, Jianmin, Thingholm, Tine, Højrup, Peter, Rönnstrand, Lars
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6004359/
https://www.ncbi.nlm.nih.gov/pubmed/29910466
http://dx.doi.org/10.1038/s41389-018-0057-3