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The Gain-Time Constant Product Quantifies Total Vestibular Output in Bilateral Vestibular Loss

Patients with inner ear damage associated with bilateral vestibular impairment often ask “how much damage do I have.” Although there are presently three clinical methods of measuring semicircular canal vestibular function; electronystagmography (ENG or VENG), rotatory chair and video head-impulse (V...

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Autores principales: Hain, Timothy C., Cherchi, Marcello, Perez-Fernandez, Nicolas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6004403/
https://www.ncbi.nlm.nih.gov/pubmed/29942279
http://dx.doi.org/10.3389/fneur.2018.00396
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author Hain, Timothy C.
Cherchi, Marcello
Perez-Fernandez, Nicolas
author_facet Hain, Timothy C.
Cherchi, Marcello
Perez-Fernandez, Nicolas
author_sort Hain, Timothy C.
collection PubMed
description Patients with inner ear damage associated with bilateral vestibular impairment often ask “how much damage do I have.” Although there are presently three clinical methods of measuring semicircular canal vestibular function; electronystagmography (ENG or VENG), rotatory chair and video head-impulse (VHIT) testing; none of these methods provides a method of measuring total vestibular output. Theory suggests that the slow cumulative eye position can be derived from the rotatory chair test by multiplying the high frequency gain by the time constant, or the “GainTc product.” In this retrospective study, we compared the GainTc in three groups, 30 normal subjects, 25 patients with surgically induced unilateral vestibular loss, and 24 patients with absent or nearly absent vestibular responses due to gentamicin exposure. We found that the GainTc product correlated better with remaining vestibular function than either the gain or the time constant alone. The fraction of remaining vestibular function was predicted by the equation R = (GainTc/11.3) – 0.6. We suggest that the GainTc product answers the question “how much damage do I have,” and is a better measure than other clinical tests of vestibular function.
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spelling pubmed-60044032018-06-25 The Gain-Time Constant Product Quantifies Total Vestibular Output in Bilateral Vestibular Loss Hain, Timothy C. Cherchi, Marcello Perez-Fernandez, Nicolas Front Neurol Neurology Patients with inner ear damage associated with bilateral vestibular impairment often ask “how much damage do I have.” Although there are presently three clinical methods of measuring semicircular canal vestibular function; electronystagmography (ENG or VENG), rotatory chair and video head-impulse (VHIT) testing; none of these methods provides a method of measuring total vestibular output. Theory suggests that the slow cumulative eye position can be derived from the rotatory chair test by multiplying the high frequency gain by the time constant, or the “GainTc product.” In this retrospective study, we compared the GainTc in three groups, 30 normal subjects, 25 patients with surgically induced unilateral vestibular loss, and 24 patients with absent or nearly absent vestibular responses due to gentamicin exposure. We found that the GainTc product correlated better with remaining vestibular function than either the gain or the time constant alone. The fraction of remaining vestibular function was predicted by the equation R = (GainTc/11.3) – 0.6. We suggest that the GainTc product answers the question “how much damage do I have,” and is a better measure than other clinical tests of vestibular function. Frontiers Media S.A. 2018-06-11 /pmc/articles/PMC6004403/ /pubmed/29942279 http://dx.doi.org/10.3389/fneur.2018.00396 Text en Copyright © 2018 Hain, Cherchi and Perez-Fernandez. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neurology
Hain, Timothy C.
Cherchi, Marcello
Perez-Fernandez, Nicolas
The Gain-Time Constant Product Quantifies Total Vestibular Output in Bilateral Vestibular Loss
title The Gain-Time Constant Product Quantifies Total Vestibular Output in Bilateral Vestibular Loss
title_full The Gain-Time Constant Product Quantifies Total Vestibular Output in Bilateral Vestibular Loss
title_fullStr The Gain-Time Constant Product Quantifies Total Vestibular Output in Bilateral Vestibular Loss
title_full_unstemmed The Gain-Time Constant Product Quantifies Total Vestibular Output in Bilateral Vestibular Loss
title_short The Gain-Time Constant Product Quantifies Total Vestibular Output in Bilateral Vestibular Loss
title_sort gain-time constant product quantifies total vestibular output in bilateral vestibular loss
topic Neurology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6004403/
https://www.ncbi.nlm.nih.gov/pubmed/29942279
http://dx.doi.org/10.3389/fneur.2018.00396
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