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Vitamin D supplementation in pregnancy and lactation to promote infant growth
BACKGROUND: Causes of early infant growth restriction remain incompletely understood. Where vitamin D deficiency is common, vitamin D supplementation during pregnancy and lactation may improve fetal-infant growth and other birth outcomes. METHODS: We conducted a randomized, double-blind, placebo-con...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Massachusetts Medical Society
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6004541/ https://www.ncbi.nlm.nih.gov/pubmed/30089075 http://dx.doi.org/10.1056/NEJMoa1800927 |
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author | Roth, Daniel E. Morris, Shaun K. Zlotkin, Stanley Gernand, Alison D. Ahmed, Tahmeed Shanta, Shaila Sharmeen Papp, Eszter Korsiak, Jill Shi, Joy Islam, M. Munirul Jahan, Ishrat Keya, Farhana Khanam Willan, Andrew R. Weksberg, Rosanna Mohsin, Minhazul Rahman, Qazi Sadeq-ur Shah, Prakesh S. Murphy, Kellie E. Stimec, Jennifer Pell, Lisa G. Qamar, Huma Al Mahmud, Abdullah |
author_facet | Roth, Daniel E. Morris, Shaun K. Zlotkin, Stanley Gernand, Alison D. Ahmed, Tahmeed Shanta, Shaila Sharmeen Papp, Eszter Korsiak, Jill Shi, Joy Islam, M. Munirul Jahan, Ishrat Keya, Farhana Khanam Willan, Andrew R. Weksberg, Rosanna Mohsin, Minhazul Rahman, Qazi Sadeq-ur Shah, Prakesh S. Murphy, Kellie E. Stimec, Jennifer Pell, Lisa G. Qamar, Huma Al Mahmud, Abdullah |
author_sort | Roth, Daniel E. |
collection | PubMed |
description | BACKGROUND: Causes of early infant growth restriction remain incompletely understood. Where vitamin D deficiency is common, vitamin D supplementation during pregnancy and lactation may improve fetal-infant growth and other birth outcomes. METHODS: We conducted a randomized, double-blind, placebo-controlled trial of maternal vitamin D supplementation from 17-24 weeks gestation until birth or 6 months postpartum. Participants were randomly allocated to five vitamin D and/or placebo supplementation groups: (A) 0 IU/week, (B) 4200 IU/week, (C) 16800 IU/week, or (D) 28000 IU/week in pregnancy, all with 0 IU/week postpartum; or, (E) 28000 IU/week in prenatal and postpartum periods. The primary outcome was length-for-age z-score at one year of age according to World Health Organization child growth standards. RESULTS: Among 1164 infants assessed at one year of age (90% of 1300 pregnancies), there were no differences across groups in length-for-age z-scores (mean ±standard deviation): A: -0.93 ±1.05, B: -1.11 ±1.12, C: -0.97 ±0.97, D: -1.06 ±1.07, E: -0.94 ±1.00 (p=0.23). Groups were similar with respect to other anthropometric measures, birth outcomes, and morbidity. Vitamin D had dose- dependent effects on maternal and infant serum 25-hydroxyvitamin D and calcium, maternal urinary calcium excretion, and maternal parathyroid hormone concentrations. No clinical adverse events were attributed to the vitamin D intervention. CONCLUSIONS: In a population with widespread prenatal vitamin D deficiency and fetal/infant growth restriction, maternal vitamin D supplementation from mid-pregnancy until birth or 6 months postpartum does not influence fetal or infant growth, and has no beneficial or harmful effects on numerous other birth and infant outcomes. |
format | Online Article Text |
id | pubmed-6004541 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Massachusetts Medical Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-60045412018-08-09 Vitamin D supplementation in pregnancy and lactation to promote infant growth Roth, Daniel E. Morris, Shaun K. Zlotkin, Stanley Gernand, Alison D. Ahmed, Tahmeed Shanta, Shaila Sharmeen Papp, Eszter Korsiak, Jill Shi, Joy Islam, M. Munirul Jahan, Ishrat Keya, Farhana Khanam Willan, Andrew R. Weksberg, Rosanna Mohsin, Minhazul Rahman, Qazi Sadeq-ur Shah, Prakesh S. Murphy, Kellie E. Stimec, Jennifer Pell, Lisa G. Qamar, Huma Al Mahmud, Abdullah N Engl J Med Research Article BACKGROUND: Causes of early infant growth restriction remain incompletely understood. Where vitamin D deficiency is common, vitamin D supplementation during pregnancy and lactation may improve fetal-infant growth and other birth outcomes. METHODS: We conducted a randomized, double-blind, placebo-controlled trial of maternal vitamin D supplementation from 17-24 weeks gestation until birth or 6 months postpartum. Participants were randomly allocated to five vitamin D and/or placebo supplementation groups: (A) 0 IU/week, (B) 4200 IU/week, (C) 16800 IU/week, or (D) 28000 IU/week in pregnancy, all with 0 IU/week postpartum; or, (E) 28000 IU/week in prenatal and postpartum periods. The primary outcome was length-for-age z-score at one year of age according to World Health Organization child growth standards. RESULTS: Among 1164 infants assessed at one year of age (90% of 1300 pregnancies), there were no differences across groups in length-for-age z-scores (mean ±standard deviation): A: -0.93 ±1.05, B: -1.11 ±1.12, C: -0.97 ±0.97, D: -1.06 ±1.07, E: -0.94 ±1.00 (p=0.23). Groups were similar with respect to other anthropometric measures, birth outcomes, and morbidity. Vitamin D had dose- dependent effects on maternal and infant serum 25-hydroxyvitamin D and calcium, maternal urinary calcium excretion, and maternal parathyroid hormone concentrations. No clinical adverse events were attributed to the vitamin D intervention. CONCLUSIONS: In a population with widespread prenatal vitamin D deficiency and fetal/infant growth restriction, maternal vitamin D supplementation from mid-pregnancy until birth or 6 months postpartum does not influence fetal or infant growth, and has no beneficial or harmful effects on numerous other birth and infant outcomes. Massachusetts Medical Society 2018-08-09 /pmc/articles/PMC6004541/ /pubmed/30089075 http://dx.doi.org/10.1056/NEJMoa1800927 Text en Copyright © 2018 Massachusetts Medical Society. https://creativecommons.org/licenses/by/4.0/ This Author Final Manuscript is licensed for use under the CC BY license. |
spellingShingle | Research Article Roth, Daniel E. Morris, Shaun K. Zlotkin, Stanley Gernand, Alison D. Ahmed, Tahmeed Shanta, Shaila Sharmeen Papp, Eszter Korsiak, Jill Shi, Joy Islam, M. Munirul Jahan, Ishrat Keya, Farhana Khanam Willan, Andrew R. Weksberg, Rosanna Mohsin, Minhazul Rahman, Qazi Sadeq-ur Shah, Prakesh S. Murphy, Kellie E. Stimec, Jennifer Pell, Lisa G. Qamar, Huma Al Mahmud, Abdullah Vitamin D supplementation in pregnancy and lactation to promote infant growth |
title | Vitamin D supplementation in pregnancy and lactation to promote
infant growth |
title_full | Vitamin D supplementation in pregnancy and lactation to promote
infant growth |
title_fullStr | Vitamin D supplementation in pregnancy and lactation to promote
infant growth |
title_full_unstemmed | Vitamin D supplementation in pregnancy and lactation to promote
infant growth |
title_short | Vitamin D supplementation in pregnancy and lactation to promote
infant growth |
title_sort | vitamin d supplementation in pregnancy and lactation to promote
infant growth |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6004541/ https://www.ncbi.nlm.nih.gov/pubmed/30089075 http://dx.doi.org/10.1056/NEJMoa1800927 |
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