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Homogeneous Assay for Target Engagement Utilizing Bioluminescent Thermal Shift

[Image: see text] Protein thermal shift assays (TSAs) provide a means for characterizing target engagement through ligand-induced thermal stabilization. Although these assays are widely utilized for screening libraries and validating hits in drug discovery programs, they can impose encumbering opera...

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Detalles Bibliográficos
Autores principales:	Dart, Melanie L., Machleidt, Thomas, Jost, Emily, Schwinn, Marie K., Robers, Matthew B., Shi, Ce, Kirkland, Thomas A., Killoran, Michael P., Wilkinson, Jennifer M., Hartnett, James R., Zimmerman, Kristopher, Wood, Keith V.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2018
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6004564/ https://www.ncbi.nlm.nih.gov/pubmed/29937980 http://dx.doi.org/10.1021/acsmedchemlett.8b00081

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