Mitotic defects lead to neuronal aneuploidy and apoptosis in frontotemporal lobar degeneration caused by MAPT mutations

Mutant Tau (MAPT) can lead to frontotemporal lobar degeneration (FTLD). Previous studies associated MAPT mutations and altered function with aneuploidy and chromosome instability in human lymphocytes and in Drosophila development. Here we examine whether FTLD-causing mutations in human MAPT induce a...

Descripción completa

Detalles Bibliográficos
Autores principales: Caneus, Julbert, Granic, Antoneta, Rademakers, Rosa, Dickson, Dennis W., Coughlan, Christina M., Chial, Heidi J., Potter, Huntington
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Cell Biology 2018
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6004587/
https://www.ncbi.nlm.nih.gov/pubmed/29282277
http://dx.doi.org/10.1091/mbc.E17-01-0031

Ejemplares similares

Ejemplares similares