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The use of Tranexamic Acid in Total Elbow Replacement to Reduce Post-Operative Wound Infection

Background: Incidence of infection following total elbow replacement (TER) is recognised to be higher compared to hip or knee arthroplasty. Extensive swelling following TER can complicate the wound healing which might lead to infection. Tranexamic Acid (TXA) is proven to reduce blood loss peri-opera...

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Autores principales: Mannan, Syed, Ali, Mohammed, Mazur, Lukasz, Chin, Mei, Fadulelmola, Ahmed
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6004686/
https://www.ncbi.nlm.nih.gov/pubmed/29922573
http://dx.doi.org/10.7150/jbji.25610
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author Mannan, Syed
Ali, Mohammed
Mazur, Lukasz
Chin, Mei
Fadulelmola, Ahmed
author_facet Mannan, Syed
Ali, Mohammed
Mazur, Lukasz
Chin, Mei
Fadulelmola, Ahmed
author_sort Mannan, Syed
collection PubMed
description Background: Incidence of infection following total elbow replacement (TER) is recognised to be higher compared to hip or knee arthroplasty. Extensive swelling following TER can complicate the wound healing which might lead to infection. Tranexamic Acid (TXA) is proven to reduce blood loss peri-operatively which might contribute to better healing outcomes. Our aim is to assess the effect of TXA in wound healing following TER. Methods: A retrospective review of a single surgeon case series. 10 patients had TER mainly for complicated elbow fractures, four of them were relatively immune-supressed. All patients had 2 grams of TXA and antibiotics intra-operatively. All were reviewed at two weeks following surgery for wound check and removal of surgical clips. Results: Seven females and three males with a mean age of 81.5 had TER and TXA. The mean level of pre-operative haemoglobin was 134.40 g/l and the mean post-operative level was 122.70g/l. No patient in this series required blood transfusion. At two weeks and six weeks follow-up, all wound healed up with no signs of infection. Conclusion: TXA has been proven to be safe an effective way of reducing peri-operative bleeding. TXA maintains haemostasis after releasing the tourniquet and therefore reduces the swelling and wound complications post-operatively
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spelling pubmed-60046862018-06-19 The use of Tranexamic Acid in Total Elbow Replacement to Reduce Post-Operative Wound Infection Mannan, Syed Ali, Mohammed Mazur, Lukasz Chin, Mei Fadulelmola, Ahmed J Bone Jt Infect Research Paper Background: Incidence of infection following total elbow replacement (TER) is recognised to be higher compared to hip or knee arthroplasty. Extensive swelling following TER can complicate the wound healing which might lead to infection. Tranexamic Acid (TXA) is proven to reduce blood loss peri-operatively which might contribute to better healing outcomes. Our aim is to assess the effect of TXA in wound healing following TER. Methods: A retrospective review of a single surgeon case series. 10 patients had TER mainly for complicated elbow fractures, four of them were relatively immune-supressed. All patients had 2 grams of TXA and antibiotics intra-operatively. All were reviewed at two weeks following surgery for wound check and removal of surgical clips. Results: Seven females and three males with a mean age of 81.5 had TER and TXA. The mean level of pre-operative haemoglobin was 134.40 g/l and the mean post-operative level was 122.70g/l. No patient in this series required blood transfusion. At two weeks and six weeks follow-up, all wound healed up with no signs of infection. Conclusion: TXA has been proven to be safe an effective way of reducing peri-operative bleeding. TXA maintains haemostasis after releasing the tourniquet and therefore reduces the swelling and wound complications post-operatively Ivyspring International Publisher 2018-05-28 /pmc/articles/PMC6004686/ /pubmed/29922573 http://dx.doi.org/10.7150/jbji.25610 Text en © Ivyspring International Publisher This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY-NC) license (https://creativecommons.org/licenses/by-nc/4.0/). See http://ivyspring.com/terms for full terms and conditions.
spellingShingle Research Paper
Mannan, Syed
Ali, Mohammed
Mazur, Lukasz
Chin, Mei
Fadulelmola, Ahmed
The use of Tranexamic Acid in Total Elbow Replacement to Reduce Post-Operative Wound Infection
title The use of Tranexamic Acid in Total Elbow Replacement to Reduce Post-Operative Wound Infection
title_full The use of Tranexamic Acid in Total Elbow Replacement to Reduce Post-Operative Wound Infection
title_fullStr The use of Tranexamic Acid in Total Elbow Replacement to Reduce Post-Operative Wound Infection
title_full_unstemmed The use of Tranexamic Acid in Total Elbow Replacement to Reduce Post-Operative Wound Infection
title_short The use of Tranexamic Acid in Total Elbow Replacement to Reduce Post-Operative Wound Infection
title_sort use of tranexamic acid in total elbow replacement to reduce post-operative wound infection
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6004686/
https://www.ncbi.nlm.nih.gov/pubmed/29922573
http://dx.doi.org/10.7150/jbji.25610
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