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A Non-canonical Feedback Circuit for Rapid Interactions between Somatosensory Cortices

Sensory perception depends on interactions among cortical areas. These interactions are mediated by canonical patterns of connectivity in which higher areas send feedback projections to lower areas via neurons in superficial and deep layers. Here, we probed the circuit basis of interactions among tw...

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Detalles Bibliográficos
Autores principales: Minamisawa, Genki, Kwon, Sung Eun, Chevée, Maxime, Brown, Solange P., O’Connor, Daniel H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6004823/
https://www.ncbi.nlm.nih.gov/pubmed/29847801
http://dx.doi.org/10.1016/j.celrep.2018.04.115
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author Minamisawa, Genki
Kwon, Sung Eun
Chevée, Maxime
Brown, Solange P.
O’Connor, Daniel H.
author_facet Minamisawa, Genki
Kwon, Sung Eun
Chevée, Maxime
Brown, Solange P.
O’Connor, Daniel H.
author_sort Minamisawa, Genki
collection PubMed
description Sensory perception depends on interactions among cortical areas. These interactions are mediated by canonical patterns of connectivity in which higher areas send feedback projections to lower areas via neurons in superficial and deep layers. Here, we probed the circuit basis of interactions among two areas critical for touch perception in mice, whisker primary (wS1) and secondary (wS2) somatosensory cortices. Neurons in layer 4 of wS2 (S2(L4)) formed a major feedback pathway to wS1. Feedback from wS2 to wS1 was organized somatotopically. Spikes evoked by whisker deflections occurred nearly as rapidly in wS2 as in wS1, including among putative S2(L4) → S1 feedback neurons. Axons from S2(L4) → S1 neurons sent stimulus orientation-specific activity to wS1. Optogenetic excitation of S2(L4) neurons modulated activity across both wS2 and wS1, while inhibition of S2(L4) reduced orientation tuning among wS1 neurons. Thus, a non-canonical feedback circuit, originating in layer 4 of S2, rapidly modulates early tactile processing.
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spelling pubmed-60048232018-06-18 A Non-canonical Feedback Circuit for Rapid Interactions between Somatosensory Cortices Minamisawa, Genki Kwon, Sung Eun Chevée, Maxime Brown, Solange P. O’Connor, Daniel H. Cell Rep Article Sensory perception depends on interactions among cortical areas. These interactions are mediated by canonical patterns of connectivity in which higher areas send feedback projections to lower areas via neurons in superficial and deep layers. Here, we probed the circuit basis of interactions among two areas critical for touch perception in mice, whisker primary (wS1) and secondary (wS2) somatosensory cortices. Neurons in layer 4 of wS2 (S2(L4)) formed a major feedback pathway to wS1. Feedback from wS2 to wS1 was organized somatotopically. Spikes evoked by whisker deflections occurred nearly as rapidly in wS2 as in wS1, including among putative S2(L4) → S1 feedback neurons. Axons from S2(L4) → S1 neurons sent stimulus orientation-specific activity to wS1. Optogenetic excitation of S2(L4) neurons modulated activity across both wS2 and wS1, while inhibition of S2(L4) reduced orientation tuning among wS1 neurons. Thus, a non-canonical feedback circuit, originating in layer 4 of S2, rapidly modulates early tactile processing. 2018-05-29 /pmc/articles/PMC6004823/ /pubmed/29847801 http://dx.doi.org/10.1016/j.celrep.2018.04.115 Text en http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Minamisawa, Genki
Kwon, Sung Eun
Chevée, Maxime
Brown, Solange P.
O’Connor, Daniel H.
A Non-canonical Feedback Circuit for Rapid Interactions between Somatosensory Cortices
title A Non-canonical Feedback Circuit for Rapid Interactions between Somatosensory Cortices
title_full A Non-canonical Feedback Circuit for Rapid Interactions between Somatosensory Cortices
title_fullStr A Non-canonical Feedback Circuit for Rapid Interactions between Somatosensory Cortices
title_full_unstemmed A Non-canonical Feedback Circuit for Rapid Interactions between Somatosensory Cortices
title_short A Non-canonical Feedback Circuit for Rapid Interactions between Somatosensory Cortices
title_sort non-canonical feedback circuit for rapid interactions between somatosensory cortices
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6004823/
https://www.ncbi.nlm.nih.gov/pubmed/29847801
http://dx.doi.org/10.1016/j.celrep.2018.04.115
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