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A Critical Evaluation of Wet Biomarkers for Huntington’s Disease: Current Status and Ways Forward

There is an unmet clinical need for objective biomarkers to monitor disease progression and treatment response in Huntington’s disease (HD). The aim of this review is, therefore, to provide practical advice for biomarker discovery and to summarise studies on biofluid markers for HD. A PubMed search...

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Detalles Bibliográficos
Autores principales: Silajdžić, Edina, Björkqvist, Maria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: IOS Press 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6004896/
https://www.ncbi.nlm.nih.gov/pubmed/29614689
http://dx.doi.org/10.3233/JHD-170273
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author Silajdžić, Edina
Björkqvist, Maria
author_facet Silajdžić, Edina
Björkqvist, Maria
author_sort Silajdžić, Edina
collection PubMed
description There is an unmet clinical need for objective biomarkers to monitor disease progression and treatment response in Huntington’s disease (HD). The aim of this review is, therefore, to provide practical advice for biomarker discovery and to summarise studies on biofluid markers for HD. A PubMed search was performed to review literature with regard to candidate saliva, urine, blood and cerebrospinal fluid biomarkers for HD. Information has been organised into tables to allow a pragmatic approach to the discussion of the evidence and generation of practical recommendations for future studies. Many of the markers published converge on metabolic and inflammatory pathways, although changes in other analytes representing antioxidant and growth factor pathways have also been found. The most promising markers reflect neuronal and glial degeneration, particularly neurofilament light chain. International collaboration to standardise assays and study protocols, as well as to recruit sufficiently large cohorts, will facilitate future biomarker discovery and development.
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spelling pubmed-60048962018-06-25 A Critical Evaluation of Wet Biomarkers for Huntington’s Disease: Current Status and Ways Forward Silajdžić, Edina Björkqvist, Maria J Huntingtons Dis Review There is an unmet clinical need for objective biomarkers to monitor disease progression and treatment response in Huntington’s disease (HD). The aim of this review is, therefore, to provide practical advice for biomarker discovery and to summarise studies on biofluid markers for HD. A PubMed search was performed to review literature with regard to candidate saliva, urine, blood and cerebrospinal fluid biomarkers for HD. Information has been organised into tables to allow a pragmatic approach to the discussion of the evidence and generation of practical recommendations for future studies. Many of the markers published converge on metabolic and inflammatory pathways, although changes in other analytes representing antioxidant and growth factor pathways have also been found. The most promising markers reflect neuronal and glial degeneration, particularly neurofilament light chain. International collaboration to standardise assays and study protocols, as well as to recruit sufficiently large cohorts, will facilitate future biomarker discovery and development. IOS Press 2018-06-01 /pmc/articles/PMC6004896/ /pubmed/29614689 http://dx.doi.org/10.3233/JHD-170273 Text en © 2018 – IOS Press and the authors. All rights reserved https://creativecommons.org/licenses/by-nc/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution Non-Commercial (CC BY-NC 4.0) License (https://creativecommons.org/licenses/by-nc/4.0/) , which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Silajdžić, Edina
Björkqvist, Maria
A Critical Evaluation of Wet Biomarkers for Huntington’s Disease: Current Status and Ways Forward
title A Critical Evaluation of Wet Biomarkers for Huntington’s Disease: Current Status and Ways Forward
title_full A Critical Evaluation of Wet Biomarkers for Huntington’s Disease: Current Status and Ways Forward
title_fullStr A Critical Evaluation of Wet Biomarkers for Huntington’s Disease: Current Status and Ways Forward
title_full_unstemmed A Critical Evaluation of Wet Biomarkers for Huntington’s Disease: Current Status and Ways Forward
title_short A Critical Evaluation of Wet Biomarkers for Huntington’s Disease: Current Status and Ways Forward
title_sort critical evaluation of wet biomarkers for huntington’s disease: current status and ways forward
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6004896/
https://www.ncbi.nlm.nih.gov/pubmed/29614689
http://dx.doi.org/10.3233/JHD-170273
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