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Tocotrienol-Rich Fraction of Palm Oil Improves Behavioral Impairments and Regulates Metabolic Pathways in AβPP/PS1 Mice
We have recently shown that the tocotrienol-rich fraction (TRF) of palm oil, a mixture of vitamin E analogs, improves amyloid pathology in vitro and in vivo. However, precise mechanisms remain unknown. In this study, we examined the effects of long-term (10 months) TRF treatment on behavioral impair...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
IOS Press
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6004929/ https://www.ncbi.nlm.nih.gov/pubmed/29889072 http://dx.doi.org/10.3233/JAD-170880 |
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author | Durani, Lina Wati Hamezah, Hamizah Shahirah Ibrahim, Nor Faeizah Yanagisawa, Daijiro Nasaruddin, Muhammad Luqman Mori, Masaki Azizan, Kamalrul Azlan Damanhuri, Hanafi Ahmad Makpol, Suzana Wan Ngah, Wan Zurinah Tooyama, Ikuo |
author_facet | Durani, Lina Wati Hamezah, Hamizah Shahirah Ibrahim, Nor Faeizah Yanagisawa, Daijiro Nasaruddin, Muhammad Luqman Mori, Masaki Azizan, Kamalrul Azlan Damanhuri, Hanafi Ahmad Makpol, Suzana Wan Ngah, Wan Zurinah Tooyama, Ikuo |
author_sort | Durani, Lina Wati |
collection | PubMed |
description | We have recently shown that the tocotrienol-rich fraction (TRF) of palm oil, a mixture of vitamin E analogs, improves amyloid pathology in vitro and in vivo. However, precise mechanisms remain unknown. In this study, we examined the effects of long-term (10 months) TRF treatment on behavioral impairments and brain metabolites in (15 months old) AβPP/PS1 double transgenic (Tg) Alzheimer’s disease (AD) mice. The open field test, Morris water maze, and novel object recognition tasks revealed improved exploratory activity, spatial learning, and recognition memory, respectively, in TRF-treated Tg mice. Brain metabolite profiling of wild-type and Tg mice treated with and without TRF was performed using ultrahigh performance liquid chromatography (UHPLC) coupled to high-resolution accurate mass (HRAM)-orbitrap tandem mass spectrometry (MS/MS). Metabolic pathway analysis found perturbed metabolic pathways that linked to AD. TRF treatment partly ameliorated metabolic perturbations in Tg mouse hippocampus. The mechanism of this pre-emptive activity may occur via modulation of metabolic pathways dependent on Aβ interaction or independent of Aβ interaction. |
format | Online Article Text |
id | pubmed-6004929 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | IOS Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-60049292018-06-25 Tocotrienol-Rich Fraction of Palm Oil Improves Behavioral Impairments and Regulates Metabolic Pathways in AβPP/PS1 Mice Durani, Lina Wati Hamezah, Hamizah Shahirah Ibrahim, Nor Faeizah Yanagisawa, Daijiro Nasaruddin, Muhammad Luqman Mori, Masaki Azizan, Kamalrul Azlan Damanhuri, Hanafi Ahmad Makpol, Suzana Wan Ngah, Wan Zurinah Tooyama, Ikuo J Alzheimers Dis Research Article We have recently shown that the tocotrienol-rich fraction (TRF) of palm oil, a mixture of vitamin E analogs, improves amyloid pathology in vitro and in vivo. However, precise mechanisms remain unknown. In this study, we examined the effects of long-term (10 months) TRF treatment on behavioral impairments and brain metabolites in (15 months old) AβPP/PS1 double transgenic (Tg) Alzheimer’s disease (AD) mice. The open field test, Morris water maze, and novel object recognition tasks revealed improved exploratory activity, spatial learning, and recognition memory, respectively, in TRF-treated Tg mice. Brain metabolite profiling of wild-type and Tg mice treated with and without TRF was performed using ultrahigh performance liquid chromatography (UHPLC) coupled to high-resolution accurate mass (HRAM)-orbitrap tandem mass spectrometry (MS/MS). Metabolic pathway analysis found perturbed metabolic pathways that linked to AD. TRF treatment partly ameliorated metabolic perturbations in Tg mouse hippocampus. The mechanism of this pre-emptive activity may occur via modulation of metabolic pathways dependent on Aβ interaction or independent of Aβ interaction. IOS Press 2018-06-08 /pmc/articles/PMC6004929/ /pubmed/29889072 http://dx.doi.org/10.3233/JAD-170880 Text en © 2018 – IOS Press and the authors. All rights reserved https://creativecommons.org/licenses/by-nc/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution Non-Commercial (CC BY-NC 4.0) License (https://creativecommons.org/licenses/by-nc/4.0/) , which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Durani, Lina Wati Hamezah, Hamizah Shahirah Ibrahim, Nor Faeizah Yanagisawa, Daijiro Nasaruddin, Muhammad Luqman Mori, Masaki Azizan, Kamalrul Azlan Damanhuri, Hanafi Ahmad Makpol, Suzana Wan Ngah, Wan Zurinah Tooyama, Ikuo Tocotrienol-Rich Fraction of Palm Oil Improves Behavioral Impairments and Regulates Metabolic Pathways in AβPP/PS1 Mice |
title | Tocotrienol-Rich Fraction of Palm Oil Improves Behavioral Impairments and Regulates Metabolic Pathways in AβPP/PS1 Mice |
title_full | Tocotrienol-Rich Fraction of Palm Oil Improves Behavioral Impairments and Regulates Metabolic Pathways in AβPP/PS1 Mice |
title_fullStr | Tocotrienol-Rich Fraction of Palm Oil Improves Behavioral Impairments and Regulates Metabolic Pathways in AβPP/PS1 Mice |
title_full_unstemmed | Tocotrienol-Rich Fraction of Palm Oil Improves Behavioral Impairments and Regulates Metabolic Pathways in AβPP/PS1 Mice |
title_short | Tocotrienol-Rich Fraction of Palm Oil Improves Behavioral Impairments and Regulates Metabolic Pathways in AβPP/PS1 Mice |
title_sort | tocotrienol-rich fraction of palm oil improves behavioral impairments and regulates metabolic pathways in aβpp/ps1 mice |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6004929/ https://www.ncbi.nlm.nih.gov/pubmed/29889072 http://dx.doi.org/10.3233/JAD-170880 |
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