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Tocotrienol-Rich Fraction of Palm Oil Improves Behavioral Impairments and Regulates Metabolic Pathways in AβPP/PS1 Mice

We have recently shown that the tocotrienol-rich fraction (TRF) of palm oil, a mixture of vitamin E analogs, improves amyloid pathology in vitro and in vivo. However, precise mechanisms remain unknown. In this study, we examined the effects of long-term (10 months) TRF treatment on behavioral impair...

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Autores principales: Durani, Lina Wati, Hamezah, Hamizah Shahirah, Ibrahim, Nor Faeizah, Yanagisawa, Daijiro, Nasaruddin, Muhammad Luqman, Mori, Masaki, Azizan, Kamalrul Azlan, Damanhuri, Hanafi Ahmad, Makpol, Suzana, Wan Ngah, Wan Zurinah, Tooyama, Ikuo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: IOS Press 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6004929/
https://www.ncbi.nlm.nih.gov/pubmed/29889072
http://dx.doi.org/10.3233/JAD-170880
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author Durani, Lina Wati
Hamezah, Hamizah Shahirah
Ibrahim, Nor Faeizah
Yanagisawa, Daijiro
Nasaruddin, Muhammad Luqman
Mori, Masaki
Azizan, Kamalrul Azlan
Damanhuri, Hanafi Ahmad
Makpol, Suzana
Wan Ngah, Wan Zurinah
Tooyama, Ikuo
author_facet Durani, Lina Wati
Hamezah, Hamizah Shahirah
Ibrahim, Nor Faeizah
Yanagisawa, Daijiro
Nasaruddin, Muhammad Luqman
Mori, Masaki
Azizan, Kamalrul Azlan
Damanhuri, Hanafi Ahmad
Makpol, Suzana
Wan Ngah, Wan Zurinah
Tooyama, Ikuo
author_sort Durani, Lina Wati
collection PubMed
description We have recently shown that the tocotrienol-rich fraction (TRF) of palm oil, a mixture of vitamin E analogs, improves amyloid pathology in vitro and in vivo. However, precise mechanisms remain unknown. In this study, we examined the effects of long-term (10 months) TRF treatment on behavioral impairments and brain metabolites in (15 months old) AβPP/PS1 double transgenic (Tg) Alzheimer’s disease (AD) mice. The open field test, Morris water maze, and novel object recognition tasks revealed improved exploratory activity, spatial learning, and recognition memory, respectively, in TRF-treated Tg mice. Brain metabolite profiling of wild-type and Tg mice treated with and without TRF was performed using ultrahigh performance liquid chromatography (UHPLC) coupled to high-resolution accurate mass (HRAM)-orbitrap tandem mass spectrometry (MS/MS). Metabolic pathway analysis found perturbed metabolic pathways that linked to AD. TRF treatment partly ameliorated metabolic perturbations in Tg mouse hippocampus. The mechanism of this pre-emptive activity may occur via modulation of metabolic pathways dependent on Aβ interaction or independent of Aβ interaction.
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spelling pubmed-60049292018-06-25 Tocotrienol-Rich Fraction of Palm Oil Improves Behavioral Impairments and Regulates Metabolic Pathways in AβPP/PS1 Mice Durani, Lina Wati Hamezah, Hamizah Shahirah Ibrahim, Nor Faeizah Yanagisawa, Daijiro Nasaruddin, Muhammad Luqman Mori, Masaki Azizan, Kamalrul Azlan Damanhuri, Hanafi Ahmad Makpol, Suzana Wan Ngah, Wan Zurinah Tooyama, Ikuo J Alzheimers Dis Research Article We have recently shown that the tocotrienol-rich fraction (TRF) of palm oil, a mixture of vitamin E analogs, improves amyloid pathology in vitro and in vivo. However, precise mechanisms remain unknown. In this study, we examined the effects of long-term (10 months) TRF treatment on behavioral impairments and brain metabolites in (15 months old) AβPP/PS1 double transgenic (Tg) Alzheimer’s disease (AD) mice. The open field test, Morris water maze, and novel object recognition tasks revealed improved exploratory activity, spatial learning, and recognition memory, respectively, in TRF-treated Tg mice. Brain metabolite profiling of wild-type and Tg mice treated with and without TRF was performed using ultrahigh performance liquid chromatography (UHPLC) coupled to high-resolution accurate mass (HRAM)-orbitrap tandem mass spectrometry (MS/MS). Metabolic pathway analysis found perturbed metabolic pathways that linked to AD. TRF treatment partly ameliorated metabolic perturbations in Tg mouse hippocampus. The mechanism of this pre-emptive activity may occur via modulation of metabolic pathways dependent on Aβ interaction or independent of Aβ interaction. IOS Press 2018-06-08 /pmc/articles/PMC6004929/ /pubmed/29889072 http://dx.doi.org/10.3233/JAD-170880 Text en © 2018 – IOS Press and the authors. All rights reserved https://creativecommons.org/licenses/by-nc/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution Non-Commercial (CC BY-NC 4.0) License (https://creativecommons.org/licenses/by-nc/4.0/) , which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Durani, Lina Wati
Hamezah, Hamizah Shahirah
Ibrahim, Nor Faeizah
Yanagisawa, Daijiro
Nasaruddin, Muhammad Luqman
Mori, Masaki
Azizan, Kamalrul Azlan
Damanhuri, Hanafi Ahmad
Makpol, Suzana
Wan Ngah, Wan Zurinah
Tooyama, Ikuo
Tocotrienol-Rich Fraction of Palm Oil Improves Behavioral Impairments and Regulates Metabolic Pathways in AβPP/PS1 Mice
title Tocotrienol-Rich Fraction of Palm Oil Improves Behavioral Impairments and Regulates Metabolic Pathways in AβPP/PS1 Mice
title_full Tocotrienol-Rich Fraction of Palm Oil Improves Behavioral Impairments and Regulates Metabolic Pathways in AβPP/PS1 Mice
title_fullStr Tocotrienol-Rich Fraction of Palm Oil Improves Behavioral Impairments and Regulates Metabolic Pathways in AβPP/PS1 Mice
title_full_unstemmed Tocotrienol-Rich Fraction of Palm Oil Improves Behavioral Impairments and Regulates Metabolic Pathways in AβPP/PS1 Mice
title_short Tocotrienol-Rich Fraction of Palm Oil Improves Behavioral Impairments and Regulates Metabolic Pathways in AβPP/PS1 Mice
title_sort tocotrienol-rich fraction of palm oil improves behavioral impairments and regulates metabolic pathways in aβpp/ps1 mice
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6004929/
https://www.ncbi.nlm.nih.gov/pubmed/29889072
http://dx.doi.org/10.3233/JAD-170880
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