Cargando…

Tocotrienol-Rich Fraction of Palm Oil Improves Behavioral Impairments and Regulates Metabolic Pathways in AβPP/PS1 Mice

We have recently shown that the tocotrienol-rich fraction (TRF) of palm oil, a mixture of vitamin E analogs, improves amyloid pathology in vitro and in vivo. However, precise mechanisms remain unknown. In this study, we examined the effects of long-term (10 months) TRF treatment on behavioral impair...

Descripción completa

Detalles Bibliográficos
Autores principales:	Durani, Lina Wati, Hamezah, Hamizah Shahirah, Ibrahim, Nor Faeizah, Yanagisawa, Daijiro, Nasaruddin, Muhammad Luqman, Mori, Masaki, Azizan, Kamalrul Azlan, Damanhuri, Hanafi Ahmad, Makpol, Suzana, Wan Ngah, Wan Zurinah, Tooyama, Ikuo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	IOS Press 2018
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6004929/ https://www.ncbi.nlm.nih.gov/pubmed/29889072 http://dx.doi.org/10.3233/JAD-170880

Ejemplares similares

Modulation of Proteome Profile in AβPP/PS1 Mice Hippocampus, Medial Prefrontal Cortex, and Striatum by Palm Oil Derived Tocotrienol-Rich Fraction
por: Hamezah, Hamizah Shahirah, et al.
Publicado: (2019)

Tocotrienol-Rich Fraction Modulates Amyloid Pathology and Improves Cognitive Function in AβPP/PS1 Mice
por: Ibrahim, Nor Faeizah, et al.
Publicado: (2016)

The effect of α-tocopherol, α- and γ-tocotrienols on amyloid-β aggregation and disaggregation in vitro
por: Ibrahim, Nor Faeizah, et al.
Publicado: (2021)

Effects of Aging and Tocotrienol-Rich Fraction Supplementation on Brain Arginine Metabolism in Rats
por: Mazlan, Musalmah, et al.
Publicado: (2017)

Study of tau pathology in male rTg4510 mice fed with a curcumin derivative Shiga-Y5
por: Yanagisawa, Daijiro, et al.
Publicado: (2018)

Tocotrienol Rich Fraction Supplementation Modulate Brain Hippocampal Gene Expression in APPswe/PS1dE9 Alzheimer’s Disease Mouse Model
por: Wan Nasri, Wan Nurzulaikha, et al.
Publicado: (2019)

An insight into the neuroprotective and anti-neuroinflammatory effects and mechanisms of Moringa oleifera
por: Azlan, Ummi Kalthum, et al.
Publicado: (2023)

Tocotrienol-Rich Fraction Prevents Cell Cycle Arrest and Elongates Telomere Length in Senescent Human Diploid Fibroblasts
por: Makpol, Suzana, et al.
Publicado: (2011)

Differential accumulation of tau pathology between reciprocal F1 hybrids of rTg4510 mice
por: Yanagisawa, Daijiro, et al.
Publicado: (2021)

Modulatory Effects of Alpha- and Gamma-Tocopherol on the Mitochondrial Respiratory Capacity and Membrane Potential in an In Vitro Model of Alzheimer’s Disease
por: Pahrudin Arrozi, Aslina, et al.
Publicado: (2021)

Neuroprotective Effects of Casein-Derived Peptide Met-Lys-Pro (MKP) in a Hypertensive Model
por: Tada, Asuka Matsuzaki, et al.
Publicado: (2020)

Modulation of collagen synthesis and its gene expression in human skin fibroblasts by tocotrienol-rich fraction
por: Makpol, Suzana, et al.
Publicado: (2011)

Gamma-Tocotrienol Modulated Gene Expression in Senescent Human Diploid Fibroblasts as Revealed by Microarray Analysis
por: Makpol, Suzana, et al.
Publicado: (2013)

Inhibition of Mitochondrial Cytochrome c Release and Suppression of Caspases by Gamma-Tocotrienol Prevent Apoptosis and Delay Aging in Stress-Induced Premature Senescence of Skin Fibroblasts
por: Makpol, Suzana, et al.
Publicado: (2012)

Gamma-tocotrienol modulation of senescence-associated gene expression prevents cellular aging in human diploid fibroblasts
por: Makpol, Suzana, et al.
Publicado: (2012)

Tocotrienol-Rich Fraction, [6]-Gingerol and Epigallocatechin Gallate Inhibit Proliferation and Induce Apoptosis of Glioma Cancer Cells
por: Rahman, Amirah Abdul, et al.
Publicado: (2014)

γ-Tocotrienol and 6-Gingerol in Combination Synergistically Induce Cytotoxicity and Apoptosis in HT-29 and SW837 Human Colorectal Cancer Cells
por: Md Yusof, Khairunnisa’, et al.
Publicado: (2015)

γ-Tocotrienol prevents oxidative stress-induced telomere shortening in human fibroblasts derived from different aged individuals
por: Makpol, Suzana, et al.
Publicado: (2010)

Tocotrienol-Rich Fraction Ameliorates Antioxidant Defense Mechanisms and Improves Replicative Senescence-Associated Oxidative Stress in Human Myoblasts
por: Khor, Shy Cian, et al.
Publicado: (2017)

Pharmaceutical Potential of Casein-Derived Tripeptide Met-Lys-Pro: Improvement in Cognitive Impairments and Suppression of Inflammation in APP/PS1 Mice
por: Matsuzaki Tada, Asuka, et al.
Publicado: (2022)

The Tocotrienol-Rich Fraction Is Superior to Tocopherol in Promoting Myogenic Differentiation in the Prevention of Replicative Senescence of Myoblasts
por: Khor, Shy Cian, et al.
Publicado: (2016)

Comparative Effects of Biodynes, Tocotrienol-Rich Fraction, and Tocopherol in Enhancing Collagen Synthesis and Inhibiting Collagen Degradation in Stress-Induced Premature Senescence Model of Human Diploid Fibroblasts
por: Makpol, Suzana, et al.
Publicado: (2013)

Comparing Palm Oil, Tocotrienol-Rich Fraction and α-Tocopherol Supplementation on the Antioxidant Levels of Older Adults
por: Nor Azman, Nor Helwa Ezzah, et al.
Publicado: (2018)

Antioxidant enzyme activity and malondialdehyde levels can be modulated by Piper betle, tocotrienol rich fraction and Chlorella vulgaris in aging C57BL/6 mice
por: Aliahmat, Nor Syahida, et al.
Publicado: (2012)

Comparative Effects of Alpha- and Gamma-Tocopherol on Mitochondrial Functions in Alzheimer’s Disease In Vitro Model
por: Pahrudin Arrozi, Aslina, et al.
Publicado: (2020)

Alpha- and Gamma-Tocopherol Modulates the Amyloidogenic Pathway of Amyloid Precursor Protein in an in vitro Model of Alzheimer’s Disease: A Transcriptional Study
por: Pahrudin Arrozi, Aslina, et al.
Publicado: (2022)

Reversal of Myoblast Aging by Tocotrienol Rich Fraction Posttreatment
por: Lim, Jing Jye, et al.
Publicado: (2013)

A Review with Updated Perspectives on the Antiviral Potentials of Traditional Medicinal Plants and Their Prospects in Antiviral Therapy
por: Saifulazmi, Nur Fadlin, et al.
Publicado: (2022)

Gene Expression Profile in Different Age Groups and Its Association with Cognitive Function in Healthy Malay Adults in Malaysia
por: Abdul Sani, Nur Fathiah, et al.
Publicado: (2021)

Optimization of 3D Immunofluorescence Analysis and Visualization Using IMARIS and MeshLab
por: Abu Bakar, Zulzikry Hafiz, et al.
Publicado: (2023)

Tocotrienol rich fraction supplementation improved lipid profile and oxidative status in healthy older adults: A randomized controlled study
por: Chin, Siok-Fong, et al.
Publicado: (2011)

Metabolomics Profiling of Age-Associated Metabolites in Malay Population
por: Tan, Jen Kit, et al.
Publicado: (2023)

γ-Tocotrienol does not substantially protect DS neurons from hydrogen peroxide-induced oxidative injury
por: Then, Sue-Mian, et al.
Publicado: (2012)

Effect of the tocotrienol-rich fraction on the lifespan and oxidative biomarkers in Caenorhabditis elegans under oxidative stress
por: Aan, Goon Jo, et al.
Publicado: (2013)

Gamma-tocotrienol and hydroxy-chavicol synergistically inhibits growth and induces apoptosis of human glioma cells
por: Abdul Rahman, Amirah, et al.
Publicado: (2014)

Fluorine-19 Magnetic Resonance Imaging for Detection of Amyloid β Oligomers Using a Keto Form of Curcumin Derivative in a Mouse Model of Alzheimer’s Disease
por: Yanagisawa, Daijiro, et al.
Publicado: (2021)

Inhibitory Mechanism of Combined Hydroxychavicol With Epigallocatechin-3-Gallate Against Glioma Cancer Cell Lines: A Transcriptomic Analysis
por: Abdul Rahman, Amirah, et al.
Publicado: (2022)

Tocotrienol-Rich Fraction (TRF) Treatment Promotes Proliferation Capacity of Stress-Induced Premature Senescence Myoblasts and Modulates the Renewal of Satellite Cells: Microarray Analysis
por: Lim, Jing Jye, et al.
Publicado: (2019)

Piper betle induces phase I & II genes through Nrf2/ARE signaling pathway in mouse embryonic fibroblasts derived from wild type and Nrf2 knockout cells
por: Wan Hasan, Wan Nuraini, et al.
Publicado: (2014)

Elevation of tumour markers TGF-β, M(2)-PK, OV-6 and AFP in hepatocellular carcinoma (HCC)-induced rats and their suppression by microalgae Chlorella vulgaris
por: Tajul Arifin, Khaizurin, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_3d9oa04rv4v85ccvvia8nrj38e