Robust sparse accelerated failure time model for survival analysis

To identify the bio-mark genes related to disease with high dimension and low sample size gene expression data, various regression approaches with different regularization methods have been proposed to solve this problem. Nevertheless, high-noises in biological data significantly reduce the performances of methods. The accelerated failure time (AFT) modelwas designed for gene selection and survival time estimation in cancer survival analysis. In this article, we proposed a novel robust sparse accelerated failure time model (RS-AFT) through combining the least absolute deviation (LAD) and L [Formula: see text] regularization. An iterative weighted linear programming algorithm without regularization parameter tuning was proposed to solve this RS-AFT model. The results of the experiments show our method has better performancebothin gene selection and survival time estimationthan some widely used regularization methods such as lasso, elastic net and SCAD. Hence we thought the RS-AFT model may be a competitive regularization method in cancer survival analysis.