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Prevention of Transcriptional γ-globin Gene Silencing by Inducing The Hereditary Persistence of Fetal Hemoglobin Point Mutation Using Chimeraplast-Mediated Gene Targeting

OBJECTIVE: Hemoglobin F (HbF) augmentation is considered a clinically beneficial phenomenon in β-hemoglobinopathies. Prevention of γ-globin gene silencing, inspired by the hereditary persistence of fetal hemoglobin, may be a suitable strategy to upregulate HbF expression in these patients. Therefore...

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Detalles Bibliográficos
Autores principales:	Ranjbaran, Reza, Nikogoftar Zarif, Mahin, Sharifzadeh, Sedigheh, Golafshan, Habibollah, Pourfathollah, Ali Akbar
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Royan Institute 2018
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6004989/ https://www.ncbi.nlm.nih.gov/pubmed/29845784 http://dx.doi.org/10.22074/cellj.2018.5181

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