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The Potential for Treatment Shortening With Higher Rifampicin Doses: Relating Drug Exposure to Treatment Response in Patients With Pulmonary Tuberculosis

BACKGROUND: Tuberculosis remains a huge public health problem and the prolonged treatment duration obstructs effective tuberculosis control. Higher rifampicin doses have been associated with better bactericidal activity, but optimal dosing is uncertain. This analysis aimed to characterize the relati...

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Detalles Bibliográficos
Autores principales: Svensson, Elin M, Svensson, Robin J, te Brake, Lindsey H M, Boeree, Martin J, Heinrich, Norbert, Konsten, Sarah, Churchyard, Gavin, Dawson, Rodney, Diacon, Andreas H, Kibiki, Gibson S, Minja, Lilian T, Ntingiya, Nyanda E, Sanne, Ian, Gillespie, Stephen H, Hoelscher, Michael, Phillips, Patrick P J, Simonsson, Ulrika S H, Aarnoutse, Rob
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6005123/
https://www.ncbi.nlm.nih.gov/pubmed/29917079
http://dx.doi.org/10.1093/cid/ciy026