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The Potential for Treatment Shortening With Higher Rifampicin Doses: Relating Drug Exposure to Treatment Response in Patients With Pulmonary Tuberculosis
BACKGROUND: Tuberculosis remains a huge public health problem and the prolonged treatment duration obstructs effective tuberculosis control. Higher rifampicin doses have been associated with better bactericidal activity, but optimal dosing is uncertain. This analysis aimed to characterize the relati...
Autores principales: | Svensson, Elin M, Svensson, Robin J, te Brake, Lindsey H M, Boeree, Martin J, Heinrich, Norbert, Konsten, Sarah, Churchyard, Gavin, Dawson, Rodney, Diacon, Andreas H, Kibiki, Gibson S, Minja, Lilian T, Ntingiya, Nyanda E, Sanne, Ian, Gillespie, Stephen H, Hoelscher, Michael, Phillips, Patrick P J, Simonsson, Ulrika S H, Aarnoutse, Rob |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6005123/ https://www.ncbi.nlm.nih.gov/pubmed/29917079 http://dx.doi.org/10.1093/cid/ciy026 |
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