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A novel thymidylate synthase from the Vibrionales, Alteromonadales, Aeromonadales, and Pasteurellales (VAAP) clade with altered nucleotide and folate binding sites

Thymidylate synthase (TS, E.C. 2.1.1.45) is a crucial enzyme for de novo deoxythymidine monophosphate (dTMP) biosynthesis. The gene for this enzyme is thyA, which encodes the folate-dependent TS that converts deoxyuridine monophosphate group (dUMP) into (dTMP) using the cofactor 5,10-methylenetetrah...

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Detalles Bibliográficos
Autores principales:	Lopez-Zavala, Alonso A., Guevara-Hernandez, Eduardo, Vazquez-Lujan, Luz H., Sanchez-Paz, Arturo, Garcia-Orozco, Karina D., Contreras-Vergara, Carmen A., Lopez-Leal, Gamaliel, Arvizu-Flores, Aldo A., Ochoa-Leyva, Adrian, Sotelo-Mundo, Rogerio R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	PeerJ Inc. 2018
Materias:	Aquaculture, Fisheries and Fish Science
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6005164/ https://www.ncbi.nlm.nih.gov/pubmed/29922516 http://dx.doi.org/10.7717/peerj.5023

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