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Injection-Site Sarcoma in a Dog: Clinical and Pathological Findings
This case report documents the clinical and pathological findings in a dog that rapidly developed a high-grade sarcoma at the site of multiple vaccinations and follows the response to surgery and adjunct treatment with toceranib. An 11-year-old female spayed Labrador Retriever presented with dorsoce...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6005287/ https://www.ncbi.nlm.nih.gov/pubmed/29955431 http://dx.doi.org/10.1155/2017/6952634 |
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author | Jacobs, Terry M. Poehlmann, Cathy E. Kiupel, Matti |
author_facet | Jacobs, Terry M. Poehlmann, Cathy E. Kiupel, Matti |
author_sort | Jacobs, Terry M. |
collection | PubMed |
description | This case report documents the clinical and pathological findings in a dog that rapidly developed a high-grade sarcoma at the site of multiple vaccinations and follows the response to surgery and adjunct treatment with toceranib. An 11-year-old female spayed Labrador Retriever presented with dorsocervical subcutaneous masses at the injection site three weeks after receiving DA(2)PP-Lepto, Rabies, and Bordetella vaccinations. A high-grade soft tissue sarcoma was diagnosed microscopically and immunohistochemistry revealed positive expression of VEGFr, PDGFr, SCF, and EGFR. Repeat surgical resections and targeted treatment with toceranib resulted in a stable remission for nearly two years. |
format | Online Article Text |
id | pubmed-6005287 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-60052872018-06-28 Injection-Site Sarcoma in a Dog: Clinical and Pathological Findings Jacobs, Terry M. Poehlmann, Cathy E. Kiupel, Matti Case Rep Vet Med Case Report This case report documents the clinical and pathological findings in a dog that rapidly developed a high-grade sarcoma at the site of multiple vaccinations and follows the response to surgery and adjunct treatment with toceranib. An 11-year-old female spayed Labrador Retriever presented with dorsocervical subcutaneous masses at the injection site three weeks after receiving DA(2)PP-Lepto, Rabies, and Bordetella vaccinations. A high-grade soft tissue sarcoma was diagnosed microscopically and immunohistochemistry revealed positive expression of VEGFr, PDGFr, SCF, and EGFR. Repeat surgical resections and targeted treatment with toceranib resulted in a stable remission for nearly two years. Hindawi 2017-05-09 /pmc/articles/PMC6005287/ /pubmed/29955431 http://dx.doi.org/10.1155/2017/6952634 Text en Copyright © 2017 Terry M. Jacobs et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Case Report Jacobs, Terry M. Poehlmann, Cathy E. Kiupel, Matti Injection-Site Sarcoma in a Dog: Clinical and Pathological Findings |
title | Injection-Site Sarcoma in a Dog: Clinical and Pathological Findings |
title_full | Injection-Site Sarcoma in a Dog: Clinical and Pathological Findings |
title_fullStr | Injection-Site Sarcoma in a Dog: Clinical and Pathological Findings |
title_full_unstemmed | Injection-Site Sarcoma in a Dog: Clinical and Pathological Findings |
title_short | Injection-Site Sarcoma in a Dog: Clinical and Pathological Findings |
title_sort | injection-site sarcoma in a dog: clinical and pathological findings |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6005287/ https://www.ncbi.nlm.nih.gov/pubmed/29955431 http://dx.doi.org/10.1155/2017/6952634 |
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