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Injection-Site Sarcoma in a Dog: Clinical and Pathological Findings

This case report documents the clinical and pathological findings in a dog that rapidly developed a high-grade sarcoma at the site of multiple vaccinations and follows the response to surgery and adjunct treatment with toceranib. An 11-year-old female spayed Labrador Retriever presented with dorsoce...

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Detalles Bibliográficos
Autores principales: Jacobs, Terry M., Poehlmann, Cathy E., Kiupel, Matti
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6005287/
https://www.ncbi.nlm.nih.gov/pubmed/29955431
http://dx.doi.org/10.1155/2017/6952634
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author Jacobs, Terry M.
Poehlmann, Cathy E.
Kiupel, Matti
author_facet Jacobs, Terry M.
Poehlmann, Cathy E.
Kiupel, Matti
author_sort Jacobs, Terry M.
collection PubMed
description This case report documents the clinical and pathological findings in a dog that rapidly developed a high-grade sarcoma at the site of multiple vaccinations and follows the response to surgery and adjunct treatment with toceranib. An 11-year-old female spayed Labrador Retriever presented with dorsocervical subcutaneous masses at the injection site three weeks after receiving DA(2)PP-Lepto, Rabies, and Bordetella vaccinations. A high-grade soft tissue sarcoma was diagnosed microscopically and immunohistochemistry revealed positive expression of VEGFr, PDGFr, SCF, and EGFR. Repeat surgical resections and targeted treatment with toceranib resulted in a stable remission for nearly two years.
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spelling pubmed-60052872018-06-28 Injection-Site Sarcoma in a Dog: Clinical and Pathological Findings Jacobs, Terry M. Poehlmann, Cathy E. Kiupel, Matti Case Rep Vet Med Case Report This case report documents the clinical and pathological findings in a dog that rapidly developed a high-grade sarcoma at the site of multiple vaccinations and follows the response to surgery and adjunct treatment with toceranib. An 11-year-old female spayed Labrador Retriever presented with dorsocervical subcutaneous masses at the injection site three weeks after receiving DA(2)PP-Lepto, Rabies, and Bordetella vaccinations. A high-grade soft tissue sarcoma was diagnosed microscopically and immunohistochemistry revealed positive expression of VEGFr, PDGFr, SCF, and EGFR. Repeat surgical resections and targeted treatment with toceranib resulted in a stable remission for nearly two years. Hindawi 2017-05-09 /pmc/articles/PMC6005287/ /pubmed/29955431 http://dx.doi.org/10.1155/2017/6952634 Text en Copyright © 2017 Terry M. Jacobs et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Jacobs, Terry M.
Poehlmann, Cathy E.
Kiupel, Matti
Injection-Site Sarcoma in a Dog: Clinical and Pathological Findings
title Injection-Site Sarcoma in a Dog: Clinical and Pathological Findings
title_full Injection-Site Sarcoma in a Dog: Clinical and Pathological Findings
title_fullStr Injection-Site Sarcoma in a Dog: Clinical and Pathological Findings
title_full_unstemmed Injection-Site Sarcoma in a Dog: Clinical and Pathological Findings
title_short Injection-Site Sarcoma in a Dog: Clinical and Pathological Findings
title_sort injection-site sarcoma in a dog: clinical and pathological findings
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6005287/
https://www.ncbi.nlm.nih.gov/pubmed/29955431
http://dx.doi.org/10.1155/2017/6952634
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