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A two-microRNA signature as a diagnostic and prognostic marker of pancreatic adenocarcinoma
BACKGROUND AND AIM: Some cancer-specific miRNAs are dysregulated in pancreatic adenocarcinoma (PAAD) and involved in cell autophagy, differentiation, proliferation, migration, invasion, and malignant transformation. The aim of our study was to determine a panel of new diagnostic and prognostic bioma...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove Medical Press
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6005310/ https://www.ncbi.nlm.nih.gov/pubmed/29942152 http://dx.doi.org/10.2147/CMAR.S158712 |
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author | Yu, Yang Feng, Xiao Cang, Shundong |
author_facet | Yu, Yang Feng, Xiao Cang, Shundong |
author_sort | Yu, Yang |
collection | PubMed |
description | BACKGROUND AND AIM: Some cancer-specific miRNAs are dysregulated in pancreatic adenocarcinoma (PAAD) and involved in cell autophagy, differentiation, proliferation, migration, invasion, and malignant transformation. The aim of our study was to determine a panel of new diagnostic and prognostic biomarkers for PAAD. METHODS: We conducted a comprehensive analysis of global miRNA-expression profiles and corresponding prognosis information of 168 PAAD patients from the Cancer Genome Atlas data set. A total of 16 differentially expressed miRNAs were identified as aberrantly expressed in PAAD, and six of these were evaluated for use as diagnostic markers for PAAD. Next, we confirmed a two-miRNA signature significantly associated with PAAD patient diagnosis and outcome prediction. RESULTS: The panel of two miRNAs showed outstanding diagnostic performance, with sensitivity of 100% and specificity of 87.5%. Finally, we divided the PAAD patients into high-risk and low-risk groups based on the expression profile of the two miRNAs. Kaplan–Meier analysis demonstrated that patients in the high-risk group had significantly worse prognosis than patients in the low-risk group. Univariate and multivariate Cox regression analysis showed that the two-miRNA signature was an independent prognostic factor for the overall survival of PAAD patients. CONCLUSION: Taken together, the two-miRNA signature may serve as an accurate and sensitive biomarker for diagnosis and PAAD-outcome prediction, facilitating the diagnosis and potentially improving treatment outcome of PAAD. |
format | Online Article Text |
id | pubmed-6005310 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Dove Medical Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-60053102018-06-25 A two-microRNA signature as a diagnostic and prognostic marker of pancreatic adenocarcinoma Yu, Yang Feng, Xiao Cang, Shundong Cancer Manag Res Original Research BACKGROUND AND AIM: Some cancer-specific miRNAs are dysregulated in pancreatic adenocarcinoma (PAAD) and involved in cell autophagy, differentiation, proliferation, migration, invasion, and malignant transformation. The aim of our study was to determine a panel of new diagnostic and prognostic biomarkers for PAAD. METHODS: We conducted a comprehensive analysis of global miRNA-expression profiles and corresponding prognosis information of 168 PAAD patients from the Cancer Genome Atlas data set. A total of 16 differentially expressed miRNAs were identified as aberrantly expressed in PAAD, and six of these were evaluated for use as diagnostic markers for PAAD. Next, we confirmed a two-miRNA signature significantly associated with PAAD patient diagnosis and outcome prediction. RESULTS: The panel of two miRNAs showed outstanding diagnostic performance, with sensitivity of 100% and specificity of 87.5%. Finally, we divided the PAAD patients into high-risk and low-risk groups based on the expression profile of the two miRNAs. Kaplan–Meier analysis demonstrated that patients in the high-risk group had significantly worse prognosis than patients in the low-risk group. Univariate and multivariate Cox regression analysis showed that the two-miRNA signature was an independent prognostic factor for the overall survival of PAAD patients. CONCLUSION: Taken together, the two-miRNA signature may serve as an accurate and sensitive biomarker for diagnosis and PAAD-outcome prediction, facilitating the diagnosis and potentially improving treatment outcome of PAAD. Dove Medical Press 2018-06-13 /pmc/articles/PMC6005310/ /pubmed/29942152 http://dx.doi.org/10.2147/CMAR.S158712 Text en © 2018 Yu et al. This work is published and licensed by Dove Medical Press Limited The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. |
spellingShingle | Original Research Yu, Yang Feng, Xiao Cang, Shundong A two-microRNA signature as a diagnostic and prognostic marker of pancreatic adenocarcinoma |
title | A two-microRNA signature as a diagnostic and prognostic marker of pancreatic adenocarcinoma |
title_full | A two-microRNA signature as a diagnostic and prognostic marker of pancreatic adenocarcinoma |
title_fullStr | A two-microRNA signature as a diagnostic and prognostic marker of pancreatic adenocarcinoma |
title_full_unstemmed | A two-microRNA signature as a diagnostic and prognostic marker of pancreatic adenocarcinoma |
title_short | A two-microRNA signature as a diagnostic and prognostic marker of pancreatic adenocarcinoma |
title_sort | two-microrna signature as a diagnostic and prognostic marker of pancreatic adenocarcinoma |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6005310/ https://www.ncbi.nlm.nih.gov/pubmed/29942152 http://dx.doi.org/10.2147/CMAR.S158712 |
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