Cargando…

Icariside II ameliorates endothelial dysfunction by regulating the MAPK pathway via miR-126/SPRED1 in diabetic human cavernous endothelial cells

AIM: The aim of the study was to investigate whether miR-126, a regulator of MAPK signaling via targeting sprouty-related EVH1 domain-containing protein 1 (SPRED1) mRNA, is involved in the process by which icariside II (ICA II) ameliorates endothelial dysfunction in human cavernous endothelial cells...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lei, Hongen, Li, Huixi, Tian, Long, Li, Meng, Xin, Zhongcheng, Zhang, Xiaodong, Guan, Ruili
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove Medical Press 2018
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6005314/ https://www.ncbi.nlm.nih.gov/pubmed/29942117 http://dx.doi.org/10.2147/DDDT.S166734

Ejemplares similares

AB238. Effect of Icariside II on miR-126 pathway on human cavernous endothelial cells exposed to a diabetic-like environment
por: Lei, Hongen, et al.
Publicado: (2016)

AB239. Icariside II enhances endothelial nitric oxide synthase expression by suppressing miR-155 in diabetic-like human cavernous endothelial cells
por: Guan, Ruili, et al.
Publicado: (2016)

AB037. Icariside II improves human cavernous endothelial cells function by regulating miR-155/eNOS signal pathway
por: Guan, Ruili, et al.
Publicado: (2016)

AB178. Molecular biology for genitourinary system diseases and sexual dysfunction icariside II prevents high-glucose-induced injury on human cavernous endothelial cells through Akt-eNOS signaling pathway
por: Li, Huixi, et al.
Publicado: (2015)

AB184. Icariside II induces NO production in human cavernous endothelial cells via the activation of eNOS by miR-155
por: Lei, Hongen, et al.
Publicado: (2015)

Icariside II ameliorates diabetic nephropathy in streptozotocin-induced diabetic rats
por: Tian, Wenjie, et al.
Publicado: (2015)

Prophylactic Protective Effects and Its Potential Mechanisms of IcarisideII on Streptozotocin Induced Spermatogenic Dysfunction
por: Xu, Yongde, et al.
Publicado: (2014)

AB177. Implications for differentiation of endogenous stem cells: therapeutic effect from icariside II on a rat model of postprostatectomy erectile dysfunction
por: Xu, Yongde, et al.
Publicado: (2015)

Antioxidant icariside II combined with insulin restores erectile function in streptozotocin-induced type 1 diabetic rats
por: Wang, Lin, et al.
Publicado: (2015)

AB208. Antioxidant icariside II combined with insulin restores erectile function in streptozotocin-induced type 1 diabetic rats
por: Wang, Lin, et al.
Publicado: (2015)

AB176. Icariside II ameliorates diabetic nephropathy in streptozotocin-induced diabetic rats
por: Tian, Wenjie, et al.
Publicado: (2015)

AB209. Prophylactic protective effects and its potential mechanisms of icariside II on streptozotocin induced spermatogenic dysfunction
por: Xu, Yongde, et al.
Publicado: (2015)

AB042. Implications for differentiation of endogenous stem cells: therapeutic effect from icariside II on a rat model of post-prostatectomy erectile dysfunction
por: Xu, Yongde, et al.
Publicado: (2016)

Icariside II induces rapid phosphorylation of endothelial nitric oxide synthase via multiple signaling pathways
por: Song, Wenpeng, et al.
Publicado: (2022)

AB101. Therapeutic effect of low intensity pulsed ultrasound in stress urinary incontinence
por: Yang, Bicheng, et al.
Publicado: (2016)

AB117. Efficacy and mechanism of combination therapy using Icariin and daily sildenafil citrate for the treatment of erectile dysfunction in a rat model of bilateral cavernous nerves injury
por: Xu, Yongde, et al.
Publicado: (2016)

AB189. Therapeutic potential of adipose-derived stem cells based micro-tissues in a rat model of post-prostatectomy erectile dysfunction
por: Xu, Yongde, et al.
Publicado: (2014)

AB81. Therapeutic potential of adipose-derived stem cells based micro-tissues in a rat model of post-prostatectomy erectile dysfunction
por: Xu, Yongde, et al.
Publicado: (2014)

miR-126-3p contributes to sorafenib resistance in hepatocellular carcinoma via downregulating SPRED1
por: Tan, Wenliang, et al.
Publicado: (2021)

AB139. Studies on the mechanism of testicular dysfunction in the early stage of a streptozotocin induced diabetic rat model
por: Xu, Yongde, et al.
Publicado: (2014)

Sprouty-related proteins with EVH1 domain (SPRED2) prevents high-glucose induced endothelial–mesenchymal transition and endothelial injury by suppressing MAPK activation
por: Liu, Tian, et al.
Publicado: (2022)

Icariside Ⅱ Attenuates Palmitic Acid-Induced Endothelial Dysfunction Through SRPK1-Akt-eNOS Signaling Pathway
por: Gu, Yang-Yang, et al.
Publicado: (2022)

Erratum to miR-126-3p contributes to sorafenib resistance in hepatocellular carcinoma via downregulating SPRED1
Publicado: (2022)

AB180. The characteristics and therapeutic applications of low-intensity pulsed ultrasound
por: Lei, Hongen, et al.
Publicado: (2014)

AB142. The characteristics and therapeutic applications of low-intensity pulsed ultrasound
por: Lei, Hongen, et al.
Publicado: (2014)

AB140. Protective effects of insulin on erectile function in rats with streptozotocin-induced diabetes
por: Tian, Wenjie, et al.
Publicado: (2014)

Relaxin-2 Prevents Erectile Dysfunction by Cavernous Nerve, Endothelial and Histopathological Protection Effects in Rats with Bilateral Cavernous Nerve Injury
por: Liu, Kang, et al.
Publicado: (2023)

SPRED1 deletion confers resistance to MAPK inhibition in melanoma
por: Ablain, Julien, et al.
Publicado: (2020)

Stable Cavitation-Mediated Delivery of miR-126 to Endothelial Cells
por: He, Stephanie, et al.
Publicado: (2022)

miR-126-5p affects the chemosensitivity of colorectal cancer cells by regulating SPRED1, ERK1/2 pathway and apoptosis
por: Xu, Mingshi, et al.
Publicado: (2022)

AB182. Therapeutic potential of adipose-derived stem cells-based micro-tissues in a postprostatectomy erectile dysfunction rat model
por: Guan, Ruili, et al.
Publicado: (2015)

AB240. Therapeutic effects of adipose-derived stem cells-based micro-tissues on erectile dysfunction in streptozotocin-induced diabetic rats
por: Hui, Yu, et al.
Publicado: (2016)

Established Immortalized Cavernous Endothelial Cells Improve Erectile Dysfunction in Rats with Cavernous Nerve Injury
por: Bak, Sang Hong, et al.
Publicado: (2023)

Low-Intensity Shock Wave Therapy and Its Application to Erectile Dysfunction
por: Lei, Hongen, et al.
Publicado: (2013)

Upregulated METTL3 promotes metastasis of colorectal Cancer via miR-1246/SPRED2/MAPK signaling pathway
por: Peng, Wen, et al.
Publicado: (2019)

Targeting miR-200c to Ameliorate Diabetes-Induced Endothelial Dysfunction
por: Reddy, Marpadga A., et al.
Publicado: (2016)

AB102. Therapeutic potential of adipose-derived stem cells-based micro-tissues in a rat model of stress urinary incontinence
por: Li, Meng, et al.
Publicado: (2016)

Doinseunggitang Ameliorates Endothelial Dysfunction in Diabetic Atherosclerosis
por: Yoon, Jung Joo, et al.
Publicado: (2013)

Age- and glycemia-related miR-126-3p levels in plasma and endothelial cells
por: Olivieri, Fabiola, et al.
Publicado: (2014)

MiR-126-3p Is Dynamically Regulated in Endothelial-to-Mesenchymal Transition during Fibrosis
por: Jordan, Nina P., et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_oiigt46j7av3l4jnjgjoubsl9h