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Screening and identification of potential PTP1B allosteric inhibitors using in silico and in vitro approaches
Protein tyrosine phosphatase 1B (PTP1B) is a validated therapeutic target for Type 2 diabetes due to its specific role as a negative regulator of insulin signaling pathways. Discovery of active site directed PTP1B inhibitors is very challenging due to highly conserved nature of the active site and m...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6005499/ https://www.ncbi.nlm.nih.gov/pubmed/29912965 http://dx.doi.org/10.1371/journal.pone.0199020 |