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Screening and identification of potential PTP1B allosteric inhibitors using in silico and in vitro approaches

Protein tyrosine phosphatase 1B (PTP1B) is a validated therapeutic target for Type 2 diabetes due to its specific role as a negative regulator of insulin signaling pathways. Discovery of active site directed PTP1B inhibitors is very challenging due to highly conserved nature of the active site and m...

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Detalles Bibliográficos
Autores principales:	Shinde, Ranajit Nivrutti, Kumar, G. Siva, Eqbal, Shahbaz, Sobhia, M. Elizabeth
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2018
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6005499/ https://www.ncbi.nlm.nih.gov/pubmed/29912965 http://dx.doi.org/10.1371/journal.pone.0199020

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