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Life-threatening dermatoses: Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis. Impact on the Spanish public health system (2010-2015)
BACKGROUND: Stevens-Johnson Syndrome (SJS) and Toxic Epidermal Necrolysis (TEN) are serious mucocutaneous reactions. In Spain, the epidemiology and resulting expenses of these diseases are not well established. METHODOLOGY: Retrospective descriptive study using the Minimum Basic Data Set (CMBD in Sp...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6005565/ https://www.ncbi.nlm.nih.gov/pubmed/29912947 http://dx.doi.org/10.1371/journal.pone.0198582 |
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author | Velasco-Tirado, Virginia Alonso-Sardón, Montserrat Cosano-Quero, Adriana Romero-Alegría, Ángela Sánchez-los Arcos, Leire López-Bernus, Amparo Pardo-Lledías, Javier Belhassen-García, Moncef |
author_facet | Velasco-Tirado, Virginia Alonso-Sardón, Montserrat Cosano-Quero, Adriana Romero-Alegría, Ángela Sánchez-los Arcos, Leire López-Bernus, Amparo Pardo-Lledías, Javier Belhassen-García, Moncef |
author_sort | Velasco-Tirado, Virginia |
collection | PubMed |
description | BACKGROUND: Stevens-Johnson Syndrome (SJS) and Toxic Epidermal Necrolysis (TEN) are serious mucocutaneous reactions. In Spain, the epidemiology and resulting expenses of these diseases are not well established. METHODOLOGY: Retrospective descriptive study using the Minimum Basic Data Set (CMBD in Spanish) in patients admitted to hospitals of the National Health System between 2010 and 2015 with a diagnosis of SJS and TEN (combination of ICD-9 codes 695.13, 695.14, and 695.15, along with length of hospital stay). PRINCIPAL FINDINGS: A total of 1,468 patients were recorded, 773 were men (52.7%). The mean age (± SD) was 52.25 ± 26.15 years. The mean incidence rate for all diagnoses was 5.19 cases per million person-years (2.96 in SJS, 0.31 in SJS/TEN and 1.90 in TEN). 148 patients died (10.1%), 47 due to SJS (5.6%) and 90 (16.7%) due to TEN. The estimated total medical cost of SJS, SJS/TEN, and TEN in Spain was €11.576.456,18, and the average medical cost per patient was €7.885,86 ± €11.686,26, higher medical cost in TEN (€10352.46 ± €16319,93) than in SJS (€6340,05 ± €7078,85) (p<0.001). CONCLUSIONS: Older patients have a more severe clinical picture and higher mortality rates. The overall mortality of both diseases is approximately 10%, and clinical diagnosis and age were the variables with the greatest influence on mortality. This study describes a stable incidence and a similar prevalence to other European countries. Additionally, the data show a high cost due to hospitalizations. Finally, the CMBD could be a good system of epidemiological analysis for the study of infrequent diseases and hospital management of conditions such as SJS and TEN. |
format | Online Article Text |
id | pubmed-6005565 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-60055652018-06-25 Life-threatening dermatoses: Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis. Impact on the Spanish public health system (2010-2015) Velasco-Tirado, Virginia Alonso-Sardón, Montserrat Cosano-Quero, Adriana Romero-Alegría, Ángela Sánchez-los Arcos, Leire López-Bernus, Amparo Pardo-Lledías, Javier Belhassen-García, Moncef PLoS One Research Article BACKGROUND: Stevens-Johnson Syndrome (SJS) and Toxic Epidermal Necrolysis (TEN) are serious mucocutaneous reactions. In Spain, the epidemiology and resulting expenses of these diseases are not well established. METHODOLOGY: Retrospective descriptive study using the Minimum Basic Data Set (CMBD in Spanish) in patients admitted to hospitals of the National Health System between 2010 and 2015 with a diagnosis of SJS and TEN (combination of ICD-9 codes 695.13, 695.14, and 695.15, along with length of hospital stay). PRINCIPAL FINDINGS: A total of 1,468 patients were recorded, 773 were men (52.7%). The mean age (± SD) was 52.25 ± 26.15 years. The mean incidence rate for all diagnoses was 5.19 cases per million person-years (2.96 in SJS, 0.31 in SJS/TEN and 1.90 in TEN). 148 patients died (10.1%), 47 due to SJS (5.6%) and 90 (16.7%) due to TEN. The estimated total medical cost of SJS, SJS/TEN, and TEN in Spain was €11.576.456,18, and the average medical cost per patient was €7.885,86 ± €11.686,26, higher medical cost in TEN (€10352.46 ± €16319,93) than in SJS (€6340,05 ± €7078,85) (p<0.001). CONCLUSIONS: Older patients have a more severe clinical picture and higher mortality rates. The overall mortality of both diseases is approximately 10%, and clinical diagnosis and age were the variables with the greatest influence on mortality. This study describes a stable incidence and a similar prevalence to other European countries. Additionally, the data show a high cost due to hospitalizations. Finally, the CMBD could be a good system of epidemiological analysis for the study of infrequent diseases and hospital management of conditions such as SJS and TEN. Public Library of Science 2018-06-18 /pmc/articles/PMC6005565/ /pubmed/29912947 http://dx.doi.org/10.1371/journal.pone.0198582 Text en © 2018 Velasco-Tirado et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Velasco-Tirado, Virginia Alonso-Sardón, Montserrat Cosano-Quero, Adriana Romero-Alegría, Ángela Sánchez-los Arcos, Leire López-Bernus, Amparo Pardo-Lledías, Javier Belhassen-García, Moncef Life-threatening dermatoses: Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis. Impact on the Spanish public health system (2010-2015) |
title | Life-threatening dermatoses: Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis. Impact on the Spanish public health system (2010-2015) |
title_full | Life-threatening dermatoses: Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis. Impact on the Spanish public health system (2010-2015) |
title_fullStr | Life-threatening dermatoses: Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis. Impact on the Spanish public health system (2010-2015) |
title_full_unstemmed | Life-threatening dermatoses: Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis. Impact on the Spanish public health system (2010-2015) |
title_short | Life-threatening dermatoses: Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis. Impact on the Spanish public health system (2010-2015) |
title_sort | life-threatening dermatoses: stevens-johnson syndrome and toxic epidermal necrolysis. impact on the spanish public health system (2010-2015) |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6005565/ https://www.ncbi.nlm.nih.gov/pubmed/29912947 http://dx.doi.org/10.1371/journal.pone.0198582 |
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