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Space Balls Revisited: Stereological Estimates of Length With Virtual Isotropic Surface Probes
The space ball probe was fully described in the literature 15 years ago by Mouton et al. (2002). Since then, it has been used in a number of studies in the nervous system that focus on axon, dendrite, and capillary length. The length of structural parameters in tissues reflect functional aspects of...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2018
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6005839/ https://www.ncbi.nlm.nih.gov/pubmed/29946242 http://dx.doi.org/10.3389/fnana.2018.00049 |
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author | West, Mark J. |
author_facet | West, Mark J. |
author_sort | West, Mark J. |
collection | PubMed |
description | The space ball probe was fully described in the literature 15 years ago by Mouton et al. (2002). Since then, it has been used in a number of studies in the nervous system that focus on axon, dendrite, and capillary length. The length of structural parameters in tissues reflect functional aspects of the tissues. Here, some of the various applications of this methodology will be presented, along with a review of the salient features of the methodology that has resulted in new wave of quantitative morphological studies of length in the nervous system. The validity of the method is discussed in view of its widespread use along with insights into the problems associated with its application to histological tissue and future techniques for applying space balls. |
format | Online Article Text |
id | pubmed-6005839 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-60058392018-06-26 Space Balls Revisited: Stereological Estimates of Length With Virtual Isotropic Surface Probes West, Mark J. Front Neuroanat Neuroscience The space ball probe was fully described in the literature 15 years ago by Mouton et al. (2002). Since then, it has been used in a number of studies in the nervous system that focus on axon, dendrite, and capillary length. The length of structural parameters in tissues reflect functional aspects of the tissues. Here, some of the various applications of this methodology will be presented, along with a review of the salient features of the methodology that has resulted in new wave of quantitative morphological studies of length in the nervous system. The validity of the method is discussed in view of its widespread use along with insights into the problems associated with its application to histological tissue and future techniques for applying space balls. Frontiers Media S.A. 2018-06-12 /pmc/articles/PMC6005839/ /pubmed/29946242 http://dx.doi.org/10.3389/fnana.2018.00049 Text en Copyright © 2018 West. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Neuroscience West, Mark J. Space Balls Revisited: Stereological Estimates of Length With Virtual Isotropic Surface Probes |
title | Space Balls Revisited: Stereological Estimates of Length With Virtual Isotropic Surface Probes |
title_full | Space Balls Revisited: Stereological Estimates of Length With Virtual Isotropic Surface Probes |
title_fullStr | Space Balls Revisited: Stereological Estimates of Length With Virtual Isotropic Surface Probes |
title_full_unstemmed | Space Balls Revisited: Stereological Estimates of Length With Virtual Isotropic Surface Probes |
title_short | Space Balls Revisited: Stereological Estimates of Length With Virtual Isotropic Surface Probes |
title_sort | space balls revisited: stereological estimates of length with virtual isotropic surface probes |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6005839/ https://www.ncbi.nlm.nih.gov/pubmed/29946242 http://dx.doi.org/10.3389/fnana.2018.00049 |
work_keys_str_mv | AT westmarkj spaceballsrevisitedstereologicalestimatesoflengthwithvirtualisotropicsurfaceprobes |