Mechanistic Insights in the Success of Fecal Microbiota Transplants for the Treatment of Clostridium difficile Infections

Fecal microbiota transplantation has proven to be an effective treatment for infections with the gram-positive enteropathogen Clostridium difficile. Despite its effectiveness, the exact mechanisms that underlie its success are largely unclear. In this review, we highlight the pleiotropic effectors t...

Descripción completa

Detalles Bibliográficos
Autores principales: Baktash, Amoe, Terveer, Elisabeth M., Zwittink, Romy D., Hornung, Bastian V. H., Corver, Jeroen, Kuijper, Ed J., Smits, Wiep Klaas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Microbiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6005852/
https://www.ncbi.nlm.nih.gov/pubmed/29946308
http://dx.doi.org/10.3389/fmicb.2018.01242
_version_ 1783332738393178112
author Baktash, Amoe
Terveer, Elisabeth M.
Zwittink, Romy D.
Hornung, Bastian V. H.
Corver, Jeroen
Kuijper, Ed J.
Smits, Wiep Klaas
author_facet Baktash, Amoe
Terveer, Elisabeth M.
Zwittink, Romy D.
Hornung, Bastian V. H.
Corver, Jeroen
Kuijper, Ed J.
Smits, Wiep Klaas
author_sort Baktash, Amoe
collection PubMed
description Fecal microbiota transplantation has proven to be an effective treatment for infections with the gram-positive enteropathogen Clostridium difficile. Despite its effectiveness, the exact mechanisms that underlie its success are largely unclear. In this review, we highlight the pleiotropic effectors that are transferred during fecal microbiota transfer and relate this to the C. difficile lifecycle. In doing so, we show that it is likely that multiple factors contribute to the elimination of symptoms of C. difficile infections after fecal microbiota transplantation.
format Online
Article
Text
id pubmed-6005852
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-60058522018-06-26 Mechanistic Insights in the Success of Fecal Microbiota Transplants for the Treatment of Clostridium difficile Infections Baktash, Amoe Terveer, Elisabeth M. Zwittink, Romy D. Hornung, Bastian V. H. Corver, Jeroen Kuijper, Ed J. Smits, Wiep Klaas Front Microbiol Microbiology Fecal microbiota transplantation has proven to be an effective treatment for infections with the gram-positive enteropathogen Clostridium difficile. Despite its effectiveness, the exact mechanisms that underlie its success are largely unclear. In this review, we highlight the pleiotropic effectors that are transferred during fecal microbiota transfer and relate this to the C. difficile lifecycle. In doing so, we show that it is likely that multiple factors contribute to the elimination of symptoms of C. difficile infections after fecal microbiota transplantation. Frontiers Media S.A. 2018-06-12 /pmc/articles/PMC6005852/ /pubmed/29946308 http://dx.doi.org/10.3389/fmicb.2018.01242 Text en Copyright © 2018 Baktash, Terveer, Zwittink, Hornung, Corver, Kuijper and Smits. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Microbiology
Baktash, Amoe
Terveer, Elisabeth M.
Zwittink, Romy D.
Hornung, Bastian V. H.
Corver, Jeroen
Kuijper, Ed J.
Smits, Wiep Klaas
Mechanistic Insights in the Success of Fecal Microbiota Transplants for the Treatment of Clostridium difficile Infections
title Mechanistic Insights in the Success of Fecal Microbiota Transplants for the Treatment of Clostridium difficile Infections
title_full Mechanistic Insights in the Success of Fecal Microbiota Transplants for the Treatment of Clostridium difficile Infections
title_fullStr Mechanistic Insights in the Success of Fecal Microbiota Transplants for the Treatment of Clostridium difficile Infections
title_full_unstemmed Mechanistic Insights in the Success of Fecal Microbiota Transplants for the Treatment of Clostridium difficile Infections
title_short Mechanistic Insights in the Success of Fecal Microbiota Transplants for the Treatment of Clostridium difficile Infections
title_sort mechanistic insights in the success of fecal microbiota transplants for the treatment of clostridium difficile infections
topic Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6005852/
https://www.ncbi.nlm.nih.gov/pubmed/29946308
http://dx.doi.org/10.3389/fmicb.2018.01242
work_keys_str_mv AT baktashamoe mechanisticinsightsinthesuccessoffecalmicrobiotatransplantsforthetreatmentofclostridiumdifficileinfections
AT terveerelisabethm mechanisticinsightsinthesuccessoffecalmicrobiotatransplantsforthetreatmentofclostridiumdifficileinfections
AT zwittinkromyd mechanisticinsightsinthesuccessoffecalmicrobiotatransplantsforthetreatmentofclostridiumdifficileinfections
AT hornungbastianvh mechanisticinsightsinthesuccessoffecalmicrobiotatransplantsforthetreatmentofclostridiumdifficileinfections
AT corverjeroen mechanisticinsightsinthesuccessoffecalmicrobiotatransplantsforthetreatmentofclostridiumdifficileinfections
AT kuijperedj mechanisticinsightsinthesuccessoffecalmicrobiotatransplantsforthetreatmentofclostridiumdifficileinfections
AT smitswiepklaas mechanisticinsightsinthesuccessoffecalmicrobiotatransplantsforthetreatmentofclostridiumdifficileinfections

Ejemplares similares