Adeno-Associated Viral Vector Serotype DJ-Mediated Overexpression of N171-82Q-Mutant Huntingtin in the Striatum of Juvenile Mice Is a New Model for Huntington’s Disease

Huntington’s disease (HD) is an autosomal-dominant inherited neurodegenerative disorder characterized by motor, psychiatric and cognitive symptoms. HD is caused by an expansion of CAG repeats in the huntingtin (HTT) gene in various areas of the brain including striatum. There are few suitable animal...

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Detalles Bibliográficos
Autores principales: Jang, Minhee, Lee, Seung Eun, Cho, Ik-Hyun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6005874/
https://www.ncbi.nlm.nih.gov/pubmed/29946240
http://dx.doi.org/10.3389/fncel.2018.00157

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6005874/
https://www.ncbi.nlm.nih.gov/pubmed/29946240
http://dx.doi.org/10.3389/fncel.2018.00157

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