A recurrent point mutation in PRKCA is a hallmark of chordoid gliomas

Chordoid glioma (ChG) is a characteristic, slow growing, and well-circumscribed diencephalic tumor, whose mutational landscape is unknown. Here we report the analysis of 16 ChG by whole-exome and RNA-sequencing. We found that 15 ChG harbor the same PRKCA(D463H) mutation. PRKCA encodes the Protein ki...

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Detalles Bibliográficos
Autores principales: Rosenberg, Shai, Simeonova, Iva, Bielle, Franck, Verreault, Maite, Bance, Bertille, Le Roux, Isabelle, Daniau, Mailys, Nadaradjane, Arun, Gleize, Vincent, Paris, Sophie, Marie, Yannick, Giry, Marine, Polivka, Marc, Figarella-Branger, Dominique, Aubriot-Lorton, Marie-Hélène, Villa, Chiara, Vasiljevic, Alexandre, Lechapt-Zalcman, Emmanuèle, Kalamarides, Michel, Sharif, Ariane, Mokhtari, Karima, Pagnotta, Stefano Maria, Iavarone, Antonio, Lasorella, Anna, Huillard, Emmanuelle, Sanson, Marc
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6006150/
https://www.ncbi.nlm.nih.gov/pubmed/29915258
http://dx.doi.org/10.1038/s41467-018-04622-w

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