PTPRS Regulates Colorectal Cancer RAS Pathway Activity by Inactivating Erk and Preventing Its Nuclear Translocation

Colorectal cancer (CRC) growth and progression is frequently driven by RAS pathway activation through upstream growth factor receptor activation or through mutational activation of KRAS or BRAF. Here we describe an additional mechanism by which the RAS pathway may be modulated in CRC. PTPRS, a recep...

Descripción completa

Detalles Bibliográficos
Autores principales: Davis, Thomas B., Yang, Mingli, Schell, Michael J., Wang, Heiman, Ma, Le, Pledger, W. Jack, Yeatman, Timothy J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6006154/
https://www.ncbi.nlm.nih.gov/pubmed/29915291
http://dx.doi.org/10.1038/s41598-018-27584-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6006154/
https://www.ncbi.nlm.nih.gov/pubmed/29915291
http://dx.doi.org/10.1038/s41598-018-27584-x

Ejemplares similares