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Behavioral and neurobiological mechanisms of punishment: implications for psychiatric disorders
Punishment involves learning about the relationship between behavior and its adverse consequences. Punishment is fundamental to reinforcement learning, decision-making and choice, and is disrupted in psychiatric disorders such as addiction, depression, and psychopathy. However, little is known about...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer International Publishing
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6006171/ https://www.ncbi.nlm.nih.gov/pubmed/29703994 http://dx.doi.org/10.1038/s41386-018-0047-3 |
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author | Jean-Richard-Dit-Bressel, Philip Killcross, Simon McNally, Gavan P. |
author_facet | Jean-Richard-Dit-Bressel, Philip Killcross, Simon McNally, Gavan P. |
author_sort | Jean-Richard-Dit-Bressel, Philip |
collection | PubMed |
description | Punishment involves learning about the relationship between behavior and its adverse consequences. Punishment is fundamental to reinforcement learning, decision-making and choice, and is disrupted in psychiatric disorders such as addiction, depression, and psychopathy. However, little is known about the brain mechanisms of punishment and much of what is known is derived from study of superficially similar, but fundamentally distinct, forms of aversive learning such as fear conditioning and avoidance learning. Here we outline the unique conditions that support punishment, the contents of its learning, and its behavioral consequences. We consider evidence implicating GABA and monoamine neurotransmitter systems, as well as corticostriatal, amygdala, and dopamine circuits in punishment. We show how maladaptive punishment processes are implicated in addictions, impulse control disorders, psychopathy, anxiety, and depression and argue that a better understanding of the cellular, circuit, and cognitive mechanisms of punishment will make important contributions to next generation therapeutic approaches. |
format | Online Article Text |
id | pubmed-6006171 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Springer International Publishing |
record_format | MEDLINE/PubMed |
spelling | pubmed-60061712018-06-20 Behavioral and neurobiological mechanisms of punishment: implications for psychiatric disorders Jean-Richard-Dit-Bressel, Philip Killcross, Simon McNally, Gavan P. Neuropsychopharmacology Review Article Punishment involves learning about the relationship between behavior and its adverse consequences. Punishment is fundamental to reinforcement learning, decision-making and choice, and is disrupted in psychiatric disorders such as addiction, depression, and psychopathy. However, little is known about the brain mechanisms of punishment and much of what is known is derived from study of superficially similar, but fundamentally distinct, forms of aversive learning such as fear conditioning and avoidance learning. Here we outline the unique conditions that support punishment, the contents of its learning, and its behavioral consequences. We consider evidence implicating GABA and monoamine neurotransmitter systems, as well as corticostriatal, amygdala, and dopamine circuits in punishment. We show how maladaptive punishment processes are implicated in addictions, impulse control disorders, psychopathy, anxiety, and depression and argue that a better understanding of the cellular, circuit, and cognitive mechanisms of punishment will make important contributions to next generation therapeutic approaches. Springer International Publishing 2018-03-27 2018-07 /pmc/articles/PMC6006171/ /pubmed/29703994 http://dx.doi.org/10.1038/s41386-018-0047-3 Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Review Article Jean-Richard-Dit-Bressel, Philip Killcross, Simon McNally, Gavan P. Behavioral and neurobiological mechanisms of punishment: implications for psychiatric disorders |
title | Behavioral and neurobiological mechanisms of punishment: implications for psychiatric disorders |
title_full | Behavioral and neurobiological mechanisms of punishment: implications for psychiatric disorders |
title_fullStr | Behavioral and neurobiological mechanisms of punishment: implications for psychiatric disorders |
title_full_unstemmed | Behavioral and neurobiological mechanisms of punishment: implications for psychiatric disorders |
title_short | Behavioral and neurobiological mechanisms of punishment: implications for psychiatric disorders |
title_sort | behavioral and neurobiological mechanisms of punishment: implications for psychiatric disorders |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6006171/ https://www.ncbi.nlm.nih.gov/pubmed/29703994 http://dx.doi.org/10.1038/s41386-018-0047-3 |
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