A practical guide for using lithium halocarbenoids in homologation reactions

ABSTRACT: Lithium halocarbenoids are versatile reagents for accomplishing homologation processes. The fast α-elimination they suffer has been considered an important limitation for their extensive use. Herein, we present a series of practical considerations for an effective employment in the homolog...

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Detalles Bibliográficos
Autores principales: Monticelli, Serena, Rui, Marta, Castoldi, Laura, Missere, Giada, Pace, Vittorio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Vienna 2018
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6006224/
https://www.ncbi.nlm.nih.gov/pubmed/29983454
http://dx.doi.org/10.1007/s00706-018-2232-9
Descripción
Sumario:ABSTRACT: Lithium halocarbenoids are versatile reagents for accomplishing homologation processes. The fast α-elimination they suffer has been considered an important limitation for their extensive use. Herein, we present a series of practical considerations for an effective employment in the homologation of selected carbon electrophiles. GRAPHICAL ABSTRACT: [Image: see text] ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s00706-018-2232-9) contains supplementary material, which is available to authorized users.

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