Post-translational modifications in DNA topoisomerase 2α highlight the role of a eukaryote-specific residue in the ATPase domain

Type 2 DNA topoisomerases (Top2) are critical components of key protein complexes involved in DNA replication, chromosome condensation and segregation, as well as gene transcription. The Top2 were found to be the main targets of anticancer agents, leading to intensive efforts to understand their fun...

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Detalles Bibliográficos
Autores principales: Bedez, Claire, Lotz, Christophe, Batisse, Claire, Broeck, Arnaud Vanden, Stote, Roland H., Howard, Eduardo, Pradeau-Aubreton, Karine, Ruff, Marc, Lamour, Valérie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6006247/
https://www.ncbi.nlm.nih.gov/pubmed/29915179
http://dx.doi.org/10.1038/s41598-018-27606-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6006247/
https://www.ncbi.nlm.nih.gov/pubmed/29915179
http://dx.doi.org/10.1038/s41598-018-27606-8

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