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Assessment of Lower-limb Vascular Endothelial Function Based on Enclosed Zone Flow-mediated Dilation

This paper proposes a novel non-invasive method for assessing the vascular endothelial function of lower-limb arteries based on the dilation rate of air-cuff plethysmograms measured using the oscillometric approach. The principle of evaluating vascular endothelial function involves flow-mediated dil...

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Autores principales: Hirano, Harutoyo, Takama, Renjo, Matsumoto, Ryo, Tanaka, Hiroshi, Hirano, Hiroki, Soh, Zu, Ukawa, Teiji, Takayanagi, Tsuneo, Morimoto, Haruka, Nakamura, Ryuji, Saeki, Noboru, Hashimoto, Haruki, Matsui, Shogo, Kishimoto, Shinji, Oda, Nozomu, Kajikawa, Masato, Maruhashi, Tatsuya, Kawamoto, Masashi, Yoshizumi, Masao, Higashi, Yukihito, Tsuji, Toshio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6006353/
https://www.ncbi.nlm.nih.gov/pubmed/29915185
http://dx.doi.org/10.1038/s41598-018-27392-3
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author Hirano, Harutoyo
Takama, Renjo
Matsumoto, Ryo
Tanaka, Hiroshi
Hirano, Hiroki
Soh, Zu
Ukawa, Teiji
Takayanagi, Tsuneo
Morimoto, Haruka
Nakamura, Ryuji
Saeki, Noboru
Hashimoto, Haruki
Matsui, Shogo
Kishimoto, Shinji
Oda, Nozomu
Kajikawa, Masato
Maruhashi, Tatsuya
Kawamoto, Masashi
Yoshizumi, Masao
Higashi, Yukihito
Tsuji, Toshio
author_facet Hirano, Harutoyo
Takama, Renjo
Matsumoto, Ryo
Tanaka, Hiroshi
Hirano, Hiroki
Soh, Zu
Ukawa, Teiji
Takayanagi, Tsuneo
Morimoto, Haruka
Nakamura, Ryuji
Saeki, Noboru
Hashimoto, Haruki
Matsui, Shogo
Kishimoto, Shinji
Oda, Nozomu
Kajikawa, Masato
Maruhashi, Tatsuya
Kawamoto, Masashi
Yoshizumi, Masao
Higashi, Yukihito
Tsuji, Toshio
author_sort Hirano, Harutoyo
collection PubMed
description This paper proposes a novel non-invasive method for assessing the vascular endothelial function of lower-limb arteries based on the dilation rate of air-cuff plethysmograms measured using the oscillometric approach. The principle of evaluating vascular endothelial function involves flow-mediated dilation. In the study conducted, blood flow in the dorsal pedis artery was first monitored while lower-limb cuff pressure was applied using the proposed system. The results showed blood flow was interrupted when the level of pressure was at least 50 mmHg higher than the subject’s lower-limb systolic arterial pressure and that blood flow velocity increased after cuff release. Next, values of the proposed index, %ezFMD(L), for assessing the vascular endothelial function of lower-limb arteries were determined from 327 adult subjects: 87 healthy subjects, 150 subjects at high risk of arteriosclerosis and 90 patients with cardiovascular disease (CAD). The mean values and standard deviations calculated using %ezFMD(L) were 30.5 ± 12.0% for the healthy subjects, 23.6 ± 12.7% for subjects at high risk of arteriosclerosis and 14.5 ± 15.4% for patients with CAD. The %ezFMD(L) values for the subjects at high risk of arteriosclerosis and the patients with CAD were significantly lower than those for the healthy subjects (p < 0.01). The proposed method may have potential for clinical application.
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spelling pubmed-60063532018-06-26 Assessment of Lower-limb Vascular Endothelial Function Based on Enclosed Zone Flow-mediated Dilation Hirano, Harutoyo Takama, Renjo Matsumoto, Ryo Tanaka, Hiroshi Hirano, Hiroki Soh, Zu Ukawa, Teiji Takayanagi, Tsuneo Morimoto, Haruka Nakamura, Ryuji Saeki, Noboru Hashimoto, Haruki Matsui, Shogo Kishimoto, Shinji Oda, Nozomu Kajikawa, Masato Maruhashi, Tatsuya Kawamoto, Masashi Yoshizumi, Masao Higashi, Yukihito Tsuji, Toshio Sci Rep Article This paper proposes a novel non-invasive method for assessing the vascular endothelial function of lower-limb arteries based on the dilation rate of air-cuff plethysmograms measured using the oscillometric approach. The principle of evaluating vascular endothelial function involves flow-mediated dilation. In the study conducted, blood flow in the dorsal pedis artery was first monitored while lower-limb cuff pressure was applied using the proposed system. The results showed blood flow was interrupted when the level of pressure was at least 50 mmHg higher than the subject’s lower-limb systolic arterial pressure and that blood flow velocity increased after cuff release. Next, values of the proposed index, %ezFMD(L), for assessing the vascular endothelial function of lower-limb arteries were determined from 327 adult subjects: 87 healthy subjects, 150 subjects at high risk of arteriosclerosis and 90 patients with cardiovascular disease (CAD). The mean values and standard deviations calculated using %ezFMD(L) were 30.5 ± 12.0% for the healthy subjects, 23.6 ± 12.7% for subjects at high risk of arteriosclerosis and 14.5 ± 15.4% for patients with CAD. The %ezFMD(L) values for the subjects at high risk of arteriosclerosis and the patients with CAD were significantly lower than those for the healthy subjects (p < 0.01). The proposed method may have potential for clinical application. Nature Publishing Group UK 2018-06-18 /pmc/articles/PMC6006353/ /pubmed/29915185 http://dx.doi.org/10.1038/s41598-018-27392-3 Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Hirano, Harutoyo
Takama, Renjo
Matsumoto, Ryo
Tanaka, Hiroshi
Hirano, Hiroki
Soh, Zu
Ukawa, Teiji
Takayanagi, Tsuneo
Morimoto, Haruka
Nakamura, Ryuji
Saeki, Noboru
Hashimoto, Haruki
Matsui, Shogo
Kishimoto, Shinji
Oda, Nozomu
Kajikawa, Masato
Maruhashi, Tatsuya
Kawamoto, Masashi
Yoshizumi, Masao
Higashi, Yukihito
Tsuji, Toshio
Assessment of Lower-limb Vascular Endothelial Function Based on Enclosed Zone Flow-mediated Dilation
title Assessment of Lower-limb Vascular Endothelial Function Based on Enclosed Zone Flow-mediated Dilation
title_full Assessment of Lower-limb Vascular Endothelial Function Based on Enclosed Zone Flow-mediated Dilation
title_fullStr Assessment of Lower-limb Vascular Endothelial Function Based on Enclosed Zone Flow-mediated Dilation
title_full_unstemmed Assessment of Lower-limb Vascular Endothelial Function Based on Enclosed Zone Flow-mediated Dilation
title_short Assessment of Lower-limb Vascular Endothelial Function Based on Enclosed Zone Flow-mediated Dilation
title_sort assessment of lower-limb vascular endothelial function based on enclosed zone flow-mediated dilation
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6006353/
https://www.ncbi.nlm.nih.gov/pubmed/29915185
http://dx.doi.org/10.1038/s41598-018-27392-3
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