Chemical Control over T-Cell Activation in Vivo Using Deprotection of trans-Cyclooctene-Modified Epitopes

[Image: see text] Activation of a cytotoxic T-cell is a complex multistep process, and tools to study the molecular events and their dynamics that result in T-cell activation in situ and in vivo are scarce. Here, we report the design and use of conditional epitopes for time-controlled T-cell activat...

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Detalles Bibliográficos
Autores principales: van der Gracht, Anouk M. F., de Geus, Mark A. R., Camps, Marcel G. M., Ruckwardt, Tracy J., Sarris, Alexi J. C., Bremmers, Jessica, Maurits, Elmer, Pawlak, Joanna B., Posthoorn, Michelle M., Bonger, Kimberly M., Filippov, Dmitri V., Overkleeft, Herman S., Robillard, Marc S., Ossendorp, Ferry, van Kasteren, Sander I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2018
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6006443/
https://www.ncbi.nlm.nih.gov/pubmed/29733186
http://dx.doi.org/10.1021/acschembio.8b00155

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