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A novel N staging system for NPC based on IMRT and RTOG guidelines for lymph node levels: Results of a prospective multicentric clinical study

The present study aimed to investigate the cervical lymph node metastasis of nasopharyngeal carcinoma (NPC) and to establish a novel N staging standard for NPC, based on intensity modulated radiation therapy (IMRT) via a prospective multicenter clinical trial. Between January 2006 and December 2009,...

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Autores principales: Kang, Min, Zhou, Pingting, Wei, Tingting, Zhao, Tingting, Long, Jianxiong, Li, Guisheng, Yan, Haolin, Feng, Guosheng, Liu, Meilian, Zhu, Jinxian, Wang, Rensheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6006447/
https://www.ncbi.nlm.nih.gov/pubmed/29928416
http://dx.doi.org/10.3892/ol.2018.8676
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author Kang, Min
Zhou, Pingting
Wei, Tingting
Zhao, Tingting
Long, Jianxiong
Li, Guisheng
Yan, Haolin
Feng, Guosheng
Liu, Meilian
Zhu, Jinxian
Wang, Rensheng
author_facet Kang, Min
Zhou, Pingting
Wei, Tingting
Zhao, Tingting
Long, Jianxiong
Li, Guisheng
Yan, Haolin
Feng, Guosheng
Liu, Meilian
Zhu, Jinxian
Wang, Rensheng
author_sort Kang, Min
collection PubMed
description The present study aimed to investigate the cervical lymph node metastasis of nasopharyngeal carcinoma (NPC) and to establish a novel N staging standard for NPC, based on intensity modulated radiation therapy (IMRT) via a prospective multicenter clinical trial. Between January 2006 and December 2009, a total of 492 patients with NPC without distant metastasis were included in the present study. All patients were treated with IMRT. According to Radiation Therapy Oncology Group division standards, the present study proposed a novel N staging system following the review of magnetic resonance images in comparison with the 7th edition of Union for International Cancer Control/American Joint Committee on Cancer (UICC/AJCC) staging system. Retropharyngeal lymph nodes, cervical lymph node level and cervical lymph node laterality were independent prognostic factors used in multivariate analyses. According to the results of the risk variety, the present study suggested that the novel N staging system included: N0 (no lymph node metastasis), N1 [retropharyngeal or/and unilateral upper cervical (I, II, III, Va, VIIb, VIII, IX and X regions) lymph node metastasis], N2 [bilateral upper cervical (I, II, III, Va, VIIb, VIII, IX and X regions) lymph node metastasis] and N3 (lymph node metastasis in IVa and Vb regions and their lower regions). The novel N staging system proposed in the present study performs better in risk difference and distribution balance. Furthermore, the differences of 5-year curves of distant metastasis-free survival and overall survival had greater statistically significant differences compared with the 7th edition of the UICC/AJCC staging system. The present study suggested a novel N staging system for cervical lymph node metastasis of NPC, which may predict the prognosis of patients with NPC in a more objective and accurate way.
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spelling pubmed-60064472018-06-20 A novel N staging system for NPC based on IMRT and RTOG guidelines for lymph node levels: Results of a prospective multicentric clinical study Kang, Min Zhou, Pingting Wei, Tingting Zhao, Tingting Long, Jianxiong Li, Guisheng Yan, Haolin Feng, Guosheng Liu, Meilian Zhu, Jinxian Wang, Rensheng Oncol Lett Articles The present study aimed to investigate the cervical lymph node metastasis of nasopharyngeal carcinoma (NPC) and to establish a novel N staging standard for NPC, based on intensity modulated radiation therapy (IMRT) via a prospective multicenter clinical trial. Between January 2006 and December 2009, a total of 492 patients with NPC without distant metastasis were included in the present study. All patients were treated with IMRT. According to Radiation Therapy Oncology Group division standards, the present study proposed a novel N staging system following the review of magnetic resonance images in comparison with the 7th edition of Union for International Cancer Control/American Joint Committee on Cancer (UICC/AJCC) staging system. Retropharyngeal lymph nodes, cervical lymph node level and cervical lymph node laterality were independent prognostic factors used in multivariate analyses. According to the results of the risk variety, the present study suggested that the novel N staging system included: N0 (no lymph node metastasis), N1 [retropharyngeal or/and unilateral upper cervical (I, II, III, Va, VIIb, VIII, IX and X regions) lymph node metastasis], N2 [bilateral upper cervical (I, II, III, Va, VIIb, VIII, IX and X regions) lymph node metastasis] and N3 (lymph node metastasis in IVa and Vb regions and their lower regions). The novel N staging system proposed in the present study performs better in risk difference and distribution balance. Furthermore, the differences of 5-year curves of distant metastasis-free survival and overall survival had greater statistically significant differences compared with the 7th edition of the UICC/AJCC staging system. The present study suggested a novel N staging system for cervical lymph node metastasis of NPC, which may predict the prognosis of patients with NPC in a more objective and accurate way. D.A. Spandidos 2018-07 2018-05-09 /pmc/articles/PMC6006447/ /pubmed/29928416 http://dx.doi.org/10.3892/ol.2018.8676 Text en Copyright: © Kang et al. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
spellingShingle Articles
Kang, Min
Zhou, Pingting
Wei, Tingting
Zhao, Tingting
Long, Jianxiong
Li, Guisheng
Yan, Haolin
Feng, Guosheng
Liu, Meilian
Zhu, Jinxian
Wang, Rensheng
A novel N staging system for NPC based on IMRT and RTOG guidelines for lymph node levels: Results of a prospective multicentric clinical study
title A novel N staging system for NPC based on IMRT and RTOG guidelines for lymph node levels: Results of a prospective multicentric clinical study
title_full A novel N staging system for NPC based on IMRT and RTOG guidelines for lymph node levels: Results of a prospective multicentric clinical study
title_fullStr A novel N staging system for NPC based on IMRT and RTOG guidelines for lymph node levels: Results of a prospective multicentric clinical study
title_full_unstemmed A novel N staging system for NPC based on IMRT and RTOG guidelines for lymph node levels: Results of a prospective multicentric clinical study
title_short A novel N staging system for NPC based on IMRT and RTOG guidelines for lymph node levels: Results of a prospective multicentric clinical study
title_sort novel n staging system for npc based on imrt and rtog guidelines for lymph node levels: results of a prospective multicentric clinical study
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6006447/
https://www.ncbi.nlm.nih.gov/pubmed/29928416
http://dx.doi.org/10.3892/ol.2018.8676
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