Residual Complexity Does Impact Organic Chemistry and Drug Discovery: The Case of Rufomyazine and Rufomycin

[Image: see text] Residual complexity (RC) involves the impact of subtle but critical structural and biological features on drug lead validation, including unexplained effects related to unidentified impurities. RC commonly plagues drug discovery efforts due to the inherent imperfections of chromato...

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Detalles Bibliográficos
Autores principales: Choules, Mary P., Klein, Larry L., Lankin, David C., McAlpine, James B., Cho, Sang-Hyun, Cheng, Jinhua, Lee, Hanki, Suh, Joo-Won, Jaki, Birgit U., Franzblau, Scott G., Pauli, Guido F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2018
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6006449/
https://www.ncbi.nlm.nih.gov/pubmed/29792329
http://dx.doi.org/10.1021/acs.joc.8b00988

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6006449/
https://www.ncbi.nlm.nih.gov/pubmed/29792329
http://dx.doi.org/10.1021/acs.joc.8b00988

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