Asymmetric synthesis of allylic amines via hydroamination of allenes with benzophenone imine

Rhodium-catalyzed highly regio- and enantioselective hydroamination of allenes is reported. Exclusive branched selectivities and excellent enantioselectivities were achieved applying a rhodium(i)/Josiphos catalyst. This method permits the practical synthesis of valuable α-chiral allylic amines using...

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Autores principales: Xu, Kun, Wang, Yu-Hsuan, Khakyzadeh, Vahid, Breit, Bernhard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2016
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6006468/
https://www.ncbi.nlm.nih.gov/pubmed/29997823
http://dx.doi.org/10.1039/c5sc04984a
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author Xu, Kun
Wang, Yu-Hsuan
Khakyzadeh, Vahid
Breit, Bernhard
author_facet Xu, Kun
Wang, Yu-Hsuan
Khakyzadeh, Vahid
Breit, Bernhard
author_sort Xu, Kun
collection PubMed
description Rhodium-catalyzed highly regio- and enantioselective hydroamination of allenes is reported. Exclusive branched selectivities and excellent enantioselectivities were achieved applying a rhodium(i)/Josiphos catalyst. This method permits the practical synthesis of valuable α-chiral allylic amines using benzophenone imine as ammonia carrier.
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spelling pubmed-60064682018-07-11 Asymmetric synthesis of allylic amines via hydroamination of allenes with benzophenone imine Xu, Kun Wang, Yu-Hsuan Khakyzadeh, Vahid Breit, Bernhard Chem Sci Chemistry Rhodium-catalyzed highly regio- and enantioselective hydroamination of allenes is reported. Exclusive branched selectivities and excellent enantioselectivities were achieved applying a rhodium(i)/Josiphos catalyst. This method permits the practical synthesis of valuable α-chiral allylic amines using benzophenone imine as ammonia carrier. Royal Society of Chemistry 2016-05-01 2016-02-09 /pmc/articles/PMC6006468/ /pubmed/29997823 http://dx.doi.org/10.1039/c5sc04984a Text en This journal is © The Royal Society of Chemistry 2016 http://creativecommons.org/licenses/by/3.0/ This article is freely available. This article is licensed under a Creative Commons Attribution 3.0 Unported Licence (CC BY 3.0)
spellingShingle Chemistry
Xu, Kun
Wang, Yu-Hsuan
Khakyzadeh, Vahid
Breit, Bernhard
Asymmetric synthesis of allylic amines via hydroamination of allenes with benzophenone imine
title Asymmetric synthesis of allylic amines via hydroamination of allenes with benzophenone imine
title_full Asymmetric synthesis of allylic amines via hydroamination of allenes with benzophenone imine
title_fullStr Asymmetric synthesis of allylic amines via hydroamination of allenes with benzophenone imine
title_full_unstemmed Asymmetric synthesis of allylic amines via hydroamination of allenes with benzophenone imine
title_short Asymmetric synthesis of allylic amines via hydroamination of allenes with benzophenone imine
title_sort asymmetric synthesis of allylic amines via hydroamination of allenes with benzophenone imine
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6006468/
https://www.ncbi.nlm.nih.gov/pubmed/29997823
http://dx.doi.org/10.1039/c5sc04984a
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AT breitbernhard asymmetricsynthesisofallylicaminesviahydroaminationofalleneswithbenzophenoneimine

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