Targeting dendritic cells in pancreatic ductal adenocarcinoma

Dendritic cells (DC) are an integral part of the tumor microenvironment. Pancreatic cancer is characterized by reduced number and function of DCs, which impacts antigen presentation and contributes to immune tolerance. Recent data suggest that exosomes can mediate communication between pancreatic ca...

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Autores principales: Deicher, Anton, Andersson, Roland, Tingstedt, Bobby, Lindell, Gert, Bauden, Monika, Ansari, Daniel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6006559/
https://www.ncbi.nlm.nih.gov/pubmed/29946224
http://dx.doi.org/10.1186/s12935-018-0585-0
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author Deicher, Anton
Andersson, Roland
Tingstedt, Bobby
Lindell, Gert
Bauden, Monika
Ansari, Daniel
author_facet Deicher, Anton
Andersson, Roland
Tingstedt, Bobby
Lindell, Gert
Bauden, Monika
Ansari, Daniel
author_sort Deicher, Anton
collection PubMed
description Dendritic cells (DC) are an integral part of the tumor microenvironment. Pancreatic cancer is characterized by reduced number and function of DCs, which impacts antigen presentation and contributes to immune tolerance. Recent data suggest that exosomes can mediate communication between pancreatic cancer cells and DCs. Furthermore, levels of DCs may serve as prognostic factors. There is also growing evidence for the effectiveness of vaccination with DCs pulsed with tumor antigens to initiate adaptive cytolytic immune responses via T cells. Most experience with DC-based vaccination has been gathered for MUC1 and WT1 antigens, where clinical studies in advanced pancreatic cancer have provided encouraging results. In this review, we highlight the role of DC in the course, prognosis and treatment of pancreatic cancer.
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spelling pubmed-60065592018-06-26 Targeting dendritic cells in pancreatic ductal adenocarcinoma Deicher, Anton Andersson, Roland Tingstedt, Bobby Lindell, Gert Bauden, Monika Ansari, Daniel Cancer Cell Int Review Dendritic cells (DC) are an integral part of the tumor microenvironment. Pancreatic cancer is characterized by reduced number and function of DCs, which impacts antigen presentation and contributes to immune tolerance. Recent data suggest that exosomes can mediate communication between pancreatic cancer cells and DCs. Furthermore, levels of DCs may serve as prognostic factors. There is also growing evidence for the effectiveness of vaccination with DCs pulsed with tumor antigens to initiate adaptive cytolytic immune responses via T cells. Most experience with DC-based vaccination has been gathered for MUC1 and WT1 antigens, where clinical studies in advanced pancreatic cancer have provided encouraging results. In this review, we highlight the role of DC in the course, prognosis and treatment of pancreatic cancer. BioMed Central 2018-06-18 /pmc/articles/PMC6006559/ /pubmed/29946224 http://dx.doi.org/10.1186/s12935-018-0585-0 Text en © The Author(s) 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Review
Deicher, Anton
Andersson, Roland
Tingstedt, Bobby
Lindell, Gert
Bauden, Monika
Ansari, Daniel
Targeting dendritic cells in pancreatic ductal adenocarcinoma
title Targeting dendritic cells in pancreatic ductal adenocarcinoma
title_full Targeting dendritic cells in pancreatic ductal adenocarcinoma
title_fullStr Targeting dendritic cells in pancreatic ductal adenocarcinoma
title_full_unstemmed Targeting dendritic cells in pancreatic ductal adenocarcinoma
title_short Targeting dendritic cells in pancreatic ductal adenocarcinoma
title_sort targeting dendritic cells in pancreatic ductal adenocarcinoma
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6006559/
https://www.ncbi.nlm.nih.gov/pubmed/29946224
http://dx.doi.org/10.1186/s12935-018-0585-0
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