Cargando…

The oncogenic neurotrophin receptor tropomyosin-related kinase variant, TrkAIII

Oncogenes derived from the neurotrophin receptor tropomyosin-related kinase TrkA act as drivers in sub-populations of a wide-range of human cancers. This, combined with a recent report that both adult and childhood cancers driven by novel oncogenic TrkA chimeric-fusions exhibit profound, long-lived...

Descripción completa

Detalles Bibliográficos
Autores principales:	Farina, Antonietta Rosella, Cappabianca, Lucia, Ruggeri, Pierdomenico, Gneo, Luciana, Pellegrini, Cristina, Fargnoli, Maria-Concetta, Mackay, Andrew Reay
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2018
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6006588/ https://www.ncbi.nlm.nih.gov/pubmed/29914559 http://dx.doi.org/10.1186/s13046-018-0786-3

Ejemplares similares

Retrograde TrkAIII transport from ERGIC to ER: a re-localisation mechanism for oncogenic activity
por: Farina, Antonietta Rosella, et al.
Publicado: (2015)

TrkAIII signals endoplasmic reticulum stress to the mitochondria in neuroblastoma cells, resulting in glycolytic metabolic adaptation
por: Farina, Antonietta Rosella, et al.
Publicado: (2017)

TRAIL induces pro-apoptotic crosstalk between the TRAIL-receptor signaling pathway and TrkAIII in SH-SY5Y cells, unveiling a potential therapeutic “Achilles heel” for the TrkAIII oncoprotein in neuroblastoma
por: Gneo, Luciana, et al.
Publicado: (2016)

The Alternative TrkAIII Splice Variant, a Targetable Oncogenic Participant in Human Cutaneous Malignant Melanoma
por: Cappabianca, Lucia, et al.
Publicado: (2023)

Doxorubicin-Induced TrkAIII Activation: A Selection Mechanism for Resistant Dormant Neuroblastoma Cells
por: Cappabianca, Lucia, et al.
Publicado: (2022)

A pilot study of alternative TrkAIII splicing in Merkel cell carcinoma: a potential oncogenic mechanism and novel therapeutic target
por: Cappabianca, Lucia, et al.
Publicado: (2019)

Multidisciplinary Treatment, Including Locoregional Chemotherapy, for Merkel-Polyomavirus-Positive Merkel Cell Carcinomas: Perspectives for Patients Exhibiting Oncogenic Alternative Δ exon 6–7 TrkAIII Splicing of Neurotrophin Receptor Tropomyosin-Related Kinase A
por: Guadagni, Stefano, et al.
Publicado: (2020)

TrkAIII Promotes Microtubule Nucleation and Assembly at the Centrosome in SH-SY5Y Neuroblastoma Cells, Contributing to an Undifferentiated Anaplastic Phenotype
por: Farina, Antonietta R., et al.
Publicado: (2013)

The TrkAIII Oncoprotein Inhibits Mitochondrial Free Radical ROS-Induced Death of SH-SY5Y Neuroblastoma Cells by Augmenting SOD2 Expression and Activity at the Mitochondria, within the Context of a Tumour Stem Cell-like Phenotype
por: Ruggeri, Pierdomenico, et al.
Publicado: (2014)

NGF FLIPs TrkA onto the death TRAIL in neuroblastoma cells
por: Ruggeri, P, et al.
Publicado: (2016)

NGF sensitizes TrkA SH-SY5Y neuroblastoma cells to TRAIL-induced apoptosis
por: Ruggeri, P, et al.
Publicado: (2016)

Somatic rearrangement of the tropomyosin-receptor-kinase (trk) oncogene is rare in gastrointestinal cancer.
por: Fey, M. F., et al.
Publicado: (1988)

Mechanisms involved in selecting and maintaining neuroblastoma cancer stem cell populations, and perspectives for therapeutic targeting
por: Farina, Antonietta Rosella, et al.
Publicado: (2021)

Hypoxia-induced alternative splicing: the 11th Hallmark of Cancer
por: Farina, Antonietta Rosella, et al.
Publicado: (2020)

Gelatinase B/MMP-9 in Tumour Pathogenesis and Progression
por: Farina, Antonietta Rosella, et al.
Publicado: (2014)

Nutraceutical Preventative and Therapeutic Potential in Neuroblastoma: From Pregnancy to Early Childhood
por: Sbaffone, Maddalena, et al.
Publicado: (2022)

Discovery, characterization and potential roles of a novel NF-YAx splice variant in human neuroblastoma
por: Cappabianca, Lucia, et al.
Publicado: (2019)

Selective activation and down‐regulation of Trk receptors by neurotrophins in human neurons co‐expressing TrkB and TrkC
por: Ateaque, Sarah, et al.
Publicado: (2022)

Stimulation of the neurotrophin receptor TrkB on astrocytes drives nitric oxide production and neurodegeneration
por: Colombo, Emanuela, et al.
Publicado: (2012)

Radioligands for Tropomyosin Receptor Kinase (Trk) Positron Emission Tomography Imaging
por: Schirrmacher, Ralf, et al.
Publicado: (2019)

Methods for Identifying Patients with Tropomyosin Receptor Kinase (TRK) Fusion Cancer
por: Wong, Derek, et al.
Publicado: (2019)

The BDNF/TrkB Neurotrophin System in the Sensory Organs of Zebrafish
por: Aragona, Marialuisa, et al.
Publicado: (2022)

Tropomyosin receptor kinase (TRK) biology and the role of NTRK gene fusions in cancer
por: Amatu, A, et al.
Publicado: (2019)

Sprouty4 at the crossroads of Trk neurotrophin receptor signaling suppression by glucocorticoids
por: Ferrero Restelli, Facundo, et al.
Publicado: (2023)

Imbalance of neurotrophin receptor isoforms TrkB-FL/TrkB-T1 induces neuronal death in excitotoxicity
por: Vidaurre, Ó G, et al.
Publicado: (2012)

Development of small-molecule tropomyosin receptor kinase (TRK) inhibitors for NTRK fusion cancers
por: Jiang, Tingting, et al.
Publicado: (2021)

Tropomyosin receptor kinase B (TrkB) signalling: targeted therapy in neurogenic tumours
por: Li, Yuehua, et al.
Publicado: (2022)

Brain-Derived Neurotrophin and TrkB in Head and Neck Squamous Cell Carcinoma
por: Dudás, József, et al.
Publicado: (2019)

Presence of Functional Neurotrophin TrkB Receptors in the Rat Superior Cervical Ganglion
por: Valle-Leija, Pablo, et al.
Publicado: (2017)

Localization of Neurotrophin Specific Trk Receptors in Mechanosensory Systems of Killifish (Nothobranchius guentheri)
por: Aragona, Marialuisa, et al.
Publicado: (2021)

Neurotrophin and Trk expression by cells of the human lamina cribrosa following oxygen-glucose deprivation
por: Lambert, Wendi S, et al.
Publicado: (2004)

Neurotrophins regulate ApoER2 proteolysis through activation of the Trk signaling pathway
por: Larios, Jorge A, et al.
Publicado: (2014)

Intrinsically disordered regions couple the ligand binding and kinase activation of Trk neurotrophin receptors
por: Kot, Erik F., et al.
Publicado: (2022)

A quest for the stereo-electronic requirements for selective agonism for the neurotrophin receptors TrkA and TrkB in 17-spirocyclic-dehydroepiandrosterone derivatives
por: Narducci, Daniele, et al.
Publicado: (2023)

The Potential Role of Timosaponin-AIII in Cancer Prevention and Treatment
por: Liu, Zhaowen, et al.
Publicado: (2023)

The neurotrophin receptor, gp75, forms a complex with the receptor tyrosine kinase TrkA
Publicado: (1996)

Syntaxin-1/TI-VAMP SNAREs interact with Trk receptors and are required for neurotrophin-dependent outgrowth
por: Fuschini, Giulia, et al.
Publicado: (2018)

Trk Receptors and Neurotrophin Cross-Interactions: New Perspectives Toward Manipulating Therapeutic Side-Effects
por: Haddad, Yazan, et al.
Publicado: (2017)

The p75 Neurotrophin Receptor Facilitates TrkB Signaling and Function in Rat Hippocampal Neurons
por: Zanin, Juan P., et al.
Publicado: (2019)

The Neurotrophin Receptor TrkC as a Novel Molecular Target of the Antineuroblastoma Action of Valproic Acid
por: Dedoni, Simona, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_4qjg3hjj8ea41ldjmqr6pi7kcu