PD-L1-Expressing Radiation-Associated Angiosarcoma after Primary Breast Cancer

Radiation-associated angiosarcoma (RAAS) is a type of radiation-associated sarcoma (RAS) that develops at the previous field of radiation in breast cancer patients. Although several reports have suggested a poor prognosis for RAAS, the 5-year overall survival of RAAS is better than that of cutaneous...

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Autores principales: Takeda, Kana, Fujimura, Taku, Lyu, Chunbing, Tsukada, Akira, Tsuchiyama, Kenichiro, Hashimoto, Akira, Aiba, Setsuya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: S. Karger AG 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6006628/
https://www.ncbi.nlm.nih.gov/pubmed/29928212
http://dx.doi.org/10.1159/000489628
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author Takeda, Kana
Fujimura, Taku
Lyu, Chunbing
Tsukada, Akira
Tsuchiyama, Kenichiro
Hashimoto, Akira
Aiba, Setsuya
author_facet Takeda, Kana
Fujimura, Taku
Lyu, Chunbing
Tsukada, Akira
Tsuchiyama, Kenichiro
Hashimoto, Akira
Aiba, Setsuya
author_sort Takeda, Kana
collection PubMed
description Radiation-associated angiosarcoma (RAAS) is a type of radiation-associated sarcoma (RAS) that develops at the previous field of radiation in breast cancer patients. Although several reports have suggested a poor prognosis for RAAS, the 5-year overall survival of RAAS is better than that of cutaneous angiosarcoma (CAS), suggesting that the prognostic factors of RAAS and CAS might be different, at least in part. In this report, we describe a case of RAAS, and employed immunohistochemical (IHC) staining of PD-L1 and MMP9 as well as periostin, IL-4, and CD163. Interestingly, IHC staining revealed that the RAAS in our case was positive for PD-L1 and negative for MMP9. Moreover, the predominant stromal factor of our case was periostin, suggesting that TAMs in the present case was not immunosuppressive, but an inflammatory subtype. These results might explain, at least in part, the better prognosis of RAAS compared to CAS.
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spelling pubmed-60066282018-06-20 PD-L1-Expressing Radiation-Associated Angiosarcoma after Primary Breast Cancer Takeda, Kana Fujimura, Taku Lyu, Chunbing Tsukada, Akira Tsuchiyama, Kenichiro Hashimoto, Akira Aiba, Setsuya Case Rep Oncol Case Report Radiation-associated angiosarcoma (RAAS) is a type of radiation-associated sarcoma (RAS) that develops at the previous field of radiation in breast cancer patients. Although several reports have suggested a poor prognosis for RAAS, the 5-year overall survival of RAAS is better than that of cutaneous angiosarcoma (CAS), suggesting that the prognostic factors of RAAS and CAS might be different, at least in part. In this report, we describe a case of RAAS, and employed immunohistochemical (IHC) staining of PD-L1 and MMP9 as well as periostin, IL-4, and CD163. Interestingly, IHC staining revealed that the RAAS in our case was positive for PD-L1 and negative for MMP9. Moreover, the predominant stromal factor of our case was periostin, suggesting that TAMs in the present case was not immunosuppressive, but an inflammatory subtype. These results might explain, at least in part, the better prognosis of RAAS compared to CAS. S. Karger AG 2018-05-29 /pmc/articles/PMC6006628/ /pubmed/29928212 http://dx.doi.org/10.1159/000489628 Text en Copyright © 2018 by S. Karger AG, Basel http://creativecommons.org/licenses/by-nc/4.0/ This article is licensed under the Creative Commons Attribution-NonCommercial-4.0 International License (CC BY-NC) (http://www.karger.com/Services/OpenAccessLicense). Usage and distribution for commercial purposes requires written permission.
spellingShingle Case Report
Takeda, Kana
Fujimura, Taku
Lyu, Chunbing
Tsukada, Akira
Tsuchiyama, Kenichiro
Hashimoto, Akira
Aiba, Setsuya
PD-L1-Expressing Radiation-Associated Angiosarcoma after Primary Breast Cancer
title PD-L1-Expressing Radiation-Associated Angiosarcoma after Primary Breast Cancer
title_full PD-L1-Expressing Radiation-Associated Angiosarcoma after Primary Breast Cancer
title_fullStr PD-L1-Expressing Radiation-Associated Angiosarcoma after Primary Breast Cancer
title_full_unstemmed PD-L1-Expressing Radiation-Associated Angiosarcoma after Primary Breast Cancer
title_short PD-L1-Expressing Radiation-Associated Angiosarcoma after Primary Breast Cancer
title_sort pd-l1-expressing radiation-associated angiosarcoma after primary breast cancer
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6006628/
https://www.ncbi.nlm.nih.gov/pubmed/29928212
http://dx.doi.org/10.1159/000489628
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