Successful Treatment of Pulmonary Pleomorphic Carcinoma with Nivolumab: A Case Report

Pulmonary pleomorphic carcinoma (PPC) has a poor prognosis due to the poor results of treatment with systemic chemotherapy. We report the case of a 73-year-old woman with PPC who showed a favorable response to nivolumab. As first-line treatment for postoperative recurrence, she received carboplatin...

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Autores principales: Fujimoto, Eriko, Yokoi, Takashi, Mikami, Koji, Kanemura, Shingo, Shibata, Eisuke, Horio, Daisuke, Koda, Yuichi, Negi, Yoshiki, Akano, Yumiko, Tada, Akio, Minami, Toshiyuki, Kuribayashi, Kozo, Kijima, Takashi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: S. Karger AG 2018
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6006649/
https://www.ncbi.nlm.nih.gov/pubmed/29928213
http://dx.doi.org/10.1159/000489392
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author Fujimoto, Eriko
Yokoi, Takashi
Mikami, Koji
Kanemura, Shingo
Shibata, Eisuke
Horio, Daisuke
Koda, Yuichi
Negi, Yoshiki
Akano, Yumiko
Tada, Akio
Minami, Toshiyuki
Kuribayashi, Kozo
Kijima, Takashi
author_facet Fujimoto, Eriko
Yokoi, Takashi
Mikami, Koji
Kanemura, Shingo
Shibata, Eisuke
Horio, Daisuke
Koda, Yuichi
Negi, Yoshiki
Akano, Yumiko
Tada, Akio
Minami, Toshiyuki
Kuribayashi, Kozo
Kijima, Takashi
author_sort Fujimoto, Eriko
collection PubMed
description Pulmonary pleomorphic carcinoma (PPC) has a poor prognosis due to the poor results of treatment with systemic chemotherapy. We report the case of a 73-year-old woman with PPC who showed a favorable response to nivolumab. As first-line treatment for postoperative recurrence, she received carboplatin and nanoparticle albumin-bound paclitaxel. However, 12 months later, a new metastatic lymph node appeared. Nivolumab was administered as second-line treatment, and the patient showed a favorable prolonged response. The effects of treatment of PPC with nivolumab seem promising. The results of a future prospective study are expected to identify indicators for the treatment of PPC.
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spelling pubmed-60066492018-06-20 Successful Treatment of Pulmonary Pleomorphic Carcinoma with Nivolumab: A Case Report Fujimoto, Eriko Yokoi, Takashi Mikami, Koji Kanemura, Shingo Shibata, Eisuke Horio, Daisuke Koda, Yuichi Negi, Yoshiki Akano, Yumiko Tada, Akio Minami, Toshiyuki Kuribayashi, Kozo Kijima, Takashi Case Rep Oncol Case Report Pulmonary pleomorphic carcinoma (PPC) has a poor prognosis due to the poor results of treatment with systemic chemotherapy. We report the case of a 73-year-old woman with PPC who showed a favorable response to nivolumab. As first-line treatment for postoperative recurrence, she received carboplatin and nanoparticle albumin-bound paclitaxel. However, 12 months later, a new metastatic lymph node appeared. Nivolumab was administered as second-line treatment, and the patient showed a favorable prolonged response. The effects of treatment of PPC with nivolumab seem promising. The results of a future prospective study are expected to identify indicators for the treatment of PPC. S. Karger AG 2018-05-31 /pmc/articles/PMC6006649/ /pubmed/29928213 http://dx.doi.org/10.1159/000489392 Text en Copyright © 2018 by S. Karger AG, Basel http://creativecommons.org/licenses/by-nc/4.0/ This article is licensed under the Creative Commons Attribution-NonCommercial-4.0 International License (CC BY-NC) (http://www.karger.com/Services/OpenAccessLicense). Usage and distribution for commercial purposes requires written permission.
spellingShingle Case Report
Fujimoto, Eriko
Yokoi, Takashi
Mikami, Koji
Kanemura, Shingo
Shibata, Eisuke
Horio, Daisuke
Koda, Yuichi
Negi, Yoshiki
Akano, Yumiko
Tada, Akio
Minami, Toshiyuki
Kuribayashi, Kozo
Kijima, Takashi
Successful Treatment of Pulmonary Pleomorphic Carcinoma with Nivolumab: A Case Report
title Successful Treatment of Pulmonary Pleomorphic Carcinoma with Nivolumab: A Case Report
title_full Successful Treatment of Pulmonary Pleomorphic Carcinoma with Nivolumab: A Case Report
title_fullStr Successful Treatment of Pulmonary Pleomorphic Carcinoma with Nivolumab: A Case Report
title_full_unstemmed Successful Treatment of Pulmonary Pleomorphic Carcinoma with Nivolumab: A Case Report
title_short Successful Treatment of Pulmonary Pleomorphic Carcinoma with Nivolumab: A Case Report
title_sort successful treatment of pulmonary pleomorphic carcinoma with nivolumab: a case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6006649/
https://www.ncbi.nlm.nih.gov/pubmed/29928213
http://dx.doi.org/10.1159/000489392
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