Activated protein C plays no major roles in the inhibition of coagulation or increased fibrinolysis in acute coagulopathy of trauma-shock: a systematic review

BACKGROUND: The pathophysiological mechanisms of acute coagulopathy of trauma-shock (ACOTS) are reported to include activated protein C-mediated suppression of thrombin generation via the proteolytic inactivation of activated Factor V (FVa) and FVIIIa; an increased fibrinolysis via neutralization of...

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Detalles Bibliográficos
Autores principales: Gando, Satoshi, Mayumi, Toshihiko, Ukai, Tomohiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6006835/
https://www.ncbi.nlm.nih.gov/pubmed/29946227
http://dx.doi.org/10.1186/s12959-018-0167-3

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